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Year : 1980  |  Volume : 12  |  Issue : 4  |  Page : 253--257

Synthesis and pharmacological screening of 2’-(6-sulphonyl –6H- 7-methyl-5-oxo-4H-2, 3-dihydro-1,4-diazepino)-2,5-dimethyl-6,7-benzomorphan

Pant Jyotsna1, BC Joshi2, KK Pant3, TK Gupta4, KP Bhargava5 
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Correspondence Address:
Pant Jyotsna


. 2«SQ»- (6- Sulphonyl- 6H- 7- methyl- S-oXo- 4H- 2,3- dihydro-1, 4- diazepino)-2, 5- dimethyl-6, 7- benzomorphan (I) was obtained in three steps (i) chlorosulphonation of 2, 5-dimethyl-6, 7-benzomorphan (Ia) to 2«SQ» chlorosulphonyl-2, 5-dimethyl-6, 7-benzomorphan (Ib) (ii) followed with the candensotion of Ib with the sodium salt of ethylacetoacetate giving an intermediate Ic with (iii) subsequent reaction of Ic with ethylenediamine. It was found to possess low toxicity, significant antidepressant and analgesic activities.


How to cite this article:
Jyotsna P, Joshi B C, Pant K K, Gupta T K, Bhargava K P. Synthesis and pharmacological screening of 2’-(6-sulphonyl –6H- 7-methyl-5-oxo-4H-2, 3-dihydro-1,4-diazepino)-2,5-dimethyl-6,7-benzomorphan.Indian J Pharmacol 1980;12:253-257


How to cite this URL:
Jyotsna P, Joshi B C, Pant K K, Gupta T K, Bhargava K P. Synthesis and pharmacological screening of 2’-(6-sulphonyl –6H- 7-methyl-5-oxo-4H-2, 3-dihydro-1,4-diazepino)-2,5-dimethyl-6,7-benzomorphan. Indian J Pharmacol [serial online] 1980 [cited 2022 Jan 24 ];12:253-257
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1980;volume=12;issue=4;spage=253;epage=257;aulast=Jyotsna;type=0