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Year : 1980  |  Volume : 12  |  Issue : 2  |  Page : 109--112

Effect of 1-histidine pretreatment on the duration of pentobarbitone sleep in mice

VV Joshi1, JJ Balsara2, AG Chandorkar3 
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Correspondence Address:
V V Joshi


. Pretreatment with L-histidine, precursor of histamine, not only prolonged pentobarbitone sleeping time but also induced sleep in mice treated with a subhypnotic dose of pentobarbitone. These effects of L-histidine were effectively antagonised by prior administration of chlorcyclizine, a H1-receptor blocker. Possible mechanism involved in the potentiating effect of L-histidine on pentobarbitone hypnosis has been discussed.


How to cite this article:
Joshi V V, Balsara J J, Chandorkar A G. Effect of 1-histidine pretreatment on the duration of pentobarbitone sleep in mice.Indian J Pharmacol 1980;12:109-112


How to cite this URL:
Joshi V V, Balsara J J, Chandorkar A G. Effect of 1-histidine pretreatment on the duration of pentobarbitone sleep in mice. Indian J Pharmacol [serial online] 1980 [cited 2021 Dec 1 ];12:109-112
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1980;volume=12;issue=2;spage=109;epage=112;aulast=Joshi;type=0