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| Year : 1979 | Volume
: 11
| Issue : 4 | Page : 293--300 |
Effect of L-histidine pretreatment on haloperidol induced catalepsy and ethamphetamine stereotypy in mice
VV Joshi1, MP Muley2, JJ Balsara3, AG Chandorkar4
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Correspondence Address:
V V Joshi
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Pretreatment with L-histidine, precursor of histamine, was found to potentiate haloperido1 induced catalepsy and to antagonise methamphetamine stereotypy while pretreatment with chlorcyclizine, a H1-receptor blocker, was found to antagonise haloperidol catalepsy and to potentiate methamphetamine stereotypy: Further, chlorcyclizine was found to antagonise the potentiating effect of L-histidine on haloparidol catalepsy and also the inhibitory effect of L histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.
How to cite this article:
Joshi V V, Muley M P, Balsara J J, Chandorkar A G. Effect of L-histidine pretreatment on haloperidol induced catalepsy and ethamphetamine stereotypy in mice.Indian J Pharmacol 1979;11:293-300
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How to cite this URL:
Joshi V V, Muley M P, Balsara J J, Chandorkar A G. Effect of L-histidine pretreatment on haloperidol induced catalepsy and ethamphetamine stereotypy in mice. Indian J Pharmacol [serial online] 1979 [cited 2021 Jan 28 ];11:293-300
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1979;volume=11;issue=4;spage=293;epage=300;aulast=Joshi;type=0 |
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