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Year : 1979  |  Volume : 11  |  Issue : 4  |  Page : 293--300

Effect of L-histidine pretreatment on haloperidol induced catalepsy and ethamphetamine stereotypy in mice

VV Joshi1, MP Muley2, JJ Balsara3, AG Chandorkar4 
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Correspondence Address:
V V Joshi


. Pretreatment with L-histidine, precursor of histamine, was found to potentiate haloperido1 induced catalepsy and to antagonise methamphetamine stereotypy while pretreatment with chlorcyclizine, a H1-receptor blocker, was found to antagonise haloperidol catalepsy and to potentiate methamphetamine stereotypy: Further, chlorcyclizine was found to antagonise the potentiating effect of L-histidine on haloparidol catalepsy and also the inhibitory effect of L histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.


How to cite this article:
Joshi V V, Muley M P, Balsara J J, Chandorkar A G. Effect of L-histidine pretreatment on haloperidol induced catalepsy and ethamphetamine stereotypy in mice.Indian J Pharmacol 1979;11:293-300


How to cite this URL:
Joshi V V, Muley M P, Balsara J J, Chandorkar A G. Effect of L-histidine pretreatment on haloperidol induced catalepsy and ethamphetamine stereotypy in mice. Indian J Pharmacol [serial online] 1979 [cited 2021 Oct 26 ];11:293-300
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1979;volume=11;issue=4;spage=293;epage=300;aulast=Joshi;type=0