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Year : 1979  |  Volume : 11  |  Issue : 4  |  Page : 277--281

Intracerebroventricular administration of histamine in conscious mice induces catalepsy

MP Muley1, JJ Balsara2, AG Chandorkar3 
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Correspondence Address:
M P Muley


. Histamine (10-80 ęg), when injected intracerebroventricularly in conscious mice, was found to induce dose dependent degree of catalepsy. Histamine-induced catalepsy was antagonised by chlorcyclizine, a H1-receptor blocker, while pretreatment with metiamide, a H2-receptor blocker, had no effect on histamine-induced catalepsy. The results indicate that the cataleptic effect of histamine is mediated through activation of H1 receptors.


How to cite this article:
Muley M P, Balsara J J, Chandorkar A G. Intracerebroventricular administration of histamine in conscious mice induces catalepsy.Indian J Pharmacol 1979;11:277-281


How to cite this URL:
Muley M P, Balsara J J, Chandorkar A G. Intracerebroventricular administration of histamine in conscious mice induces catalepsy. Indian J Pharmacol [serial online] 1979 [cited 2021 Apr 21 ];11:277-281
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1979;volume=11;issue=4;spage=277;epage=281;aulast=Muley;type=0