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Year : 1979  |  Volume : 11  |  Issue : 4  |  Page : 249--255

Effect of bacterial pyrogen and prostaglandins on body temperature in pigeons

PN Saxena1, KC Singhal2, Chawla Naresh3, MBL Johri4, Iqbal Shama5 
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Correspondence Address:
P N Saxena


. The effect of bacterial endotoxin (TAB vaccine and Shigella dysenteriae somatic type 0 antigen) and the prostaglandins (PCs) has been studied on the cloacaI temperature of unanaesthetized pigeons. The endotoxin produced hypothermia which showed little dose dependance and which w as more marked after intravenous than after intracerebroventricular injection and a very delayed hyperthermia brought in relief by the circadian rhythm of the body temperature. The PGs E1 E2 F1and F2 were devoid of temperature effect when injected intraventricularly at ambient temperature between 10(-30(C. Injected intravenously, PGE, produced a small hypothermia. Intravenous injection of indomethacin, an inhibitor of PG synthesis, neither affected the normal temperature nor modified the endotoxin hypothermia. It is inferred that PGs are not involved in themoregulation and the early hypothetic effect of the endotoxin may be due to its direct action on the skin blood vessels.


How to cite this article:
Saxena P N, Singhal K C, Naresh C, Johri M, Shama I. Effect of bacterial pyrogen and prostaglandins on body temperature in pigeons.Indian J Pharmacol 1979;11:249-255


How to cite this URL:
Saxena P N, Singhal K C, Naresh C, Johri M, Shama I. Effect of bacterial pyrogen and prostaglandins on body temperature in pigeons. Indian J Pharmacol [serial online] 1979 [cited 2022 Nov 29 ];11:249-255
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1979;volume=11;issue=4;spage=249;epage=255;aulast=Saxena;type=0