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| Year : 1979 | Volume
: 11
| Issue : 3 | Page : 201--208 |
Evidence for the indirect effect of histamine in the estrogen primed rat uterus
SC Verma1, RK Goyal2
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2
Correspondence Address:
S C Verma
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Histamine and 4-methylhistamine (4-MH), a specific H2-receptor agonist produced dose related relaxation of uterine strips obtained from estrogen primed rats, while 2-(2-pyridyl) ethylamine (PEA), a specific H,-receptor agonist had no significant effect. Metiamide, the specific H2-receptor antagonist inhibited the responses to histamine and 4-MH, while mepyramine maleate, the specific H1- receptor antagonist did not produce any significant effect. Propranolol, the classical adrenergic beta-receptor antagonist also inhibited histamine and 4.MH induced relaxation of the estrogen primed rat uterus. Reserpine pretreatment (5 mg/kg) significantly reduced the histamine and 4-MH responses. Our findings suggest that histamine acts indirectly on the uterus to produce inhibition by stimulating H. receptors. H1-receptors do not appear to be present in the rat uterus.
How to cite this article:
Verma S C, Goyal R K. Evidence for the indirect effect of histamine in the estrogen primed rat uterus.Indian J Pharmacol 1979;11:201-208
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How to cite this URL:
Verma S C, Goyal R K. Evidence for the indirect effect of histamine in the estrogen primed rat uterus. Indian J Pharmacol [serial online] 1979 [cited 2023 Sep 21 ];11:201-208
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1979;volume=11;issue=3;spage=201;epage=208;aulast=Verma;type=0 |
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