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Year : 1979  |  Volume : 11  |  Issue : 2  |  Page : 113--118

In vitro effects of cyclic AMP, L-dopa and 6-hydroxydopamine on rat brain dopamine - beta - hydroxylase

Srivastava Madhulika1, NK Kapoor2 
1 
2 

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Srivastava Madhulika


. Dopamine-f-hydroxylase (DBH activity of rat brain was found to be stimulated by cyclic tand L- DOPA. The stimulation of enzyme activity increased with increasing concentration of the activators. 6 -hydroxydopamine (6-OHDA) caused an inhibition of brain DBH activity which may be due to the degeneration of adrenergic neurons. .The inhibitory effect was partially prevented in presence of cAMP or GDOPA.


How to cite this article:
Madhulika S, Kapoor N K. In vitro effects of cyclic AMP, L-dopa and 6-hydroxydopamine on rat brain dopamine - beta - hydroxylase.Indian J Pharmacol 1979;11:113-118


How to cite this URL:
Madhulika S, Kapoor N K. In vitro effects of cyclic AMP, L-dopa and 6-hydroxydopamine on rat brain dopamine - beta - hydroxylase. Indian J Pharmacol [serial online] 1979 [cited 2022 May 21 ];11:113-118
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1979;volume=11;issue=2;spage=113;epage=118;aulast=Madhulika;type=0