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Year : 1979  |  Volume : 11  |  Issue : 2  |  Page : 107--111

Antihistaminic activity of 4-fluoro-3-(1-piperidyl)propiophenon-a centrally acting skeletal muscle relaxant

GK Patnaik1, M Sabir2, BN Dhawan3 
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Correspondence Address:
G K Patnaik


. In concentration of 0.1-I(g/ml, compound 4-fluoro-3-(l-piperidyl) propiophenone produce+ dose dependent reversible inhibition of the spasmogenic effect of histamine on isolated guinea-pig ileum without altering its response to acetylcholine, 5 -hydroxytryptamine, incotine and KCI. On the isolated guineapig atria 2 (g/ml of the compound inhibited the positive chronotropic and inotropic effect of both histamine and adrenaline In doses of 2.5-10 mg/kg it reduced by about 80%, the hypotension induced by histamine but not that by acetylcholine or isopranalino in anaesthetised cat. The inhibitory effect lasted for 40.70 min. In the Konzett-Rossler preparation of guinea-pig, it (1mg/kg) blocked the broncho constriction induced by histamine without altering that by acetylcholine, It also protected the guineapigs from histamine induced bronchospasm as well as death due to intravenously administered histamine.


How to cite this article:
Patnaik G K, Sabir M, Dhawan B N. Antihistaminic activity of 4-fluoro-3-(1-piperidyl)propiophenon-a centrally acting skeletal muscle relaxant.Indian J Pharmacol 1979;11:107-111


How to cite this URL:
Patnaik G K, Sabir M, Dhawan B N. Antihistaminic activity of 4-fluoro-3-(1-piperidyl)propiophenon-a centrally acting skeletal muscle relaxant. Indian J Pharmacol [serial online] 1979 [cited 2022 Dec 8 ];11:107-111
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1979;volume=11;issue=2;spage=107;epage=111;aulast=Patnaik;type=0