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Year : 1978  |  Volume : 10  |  Issue : 4  |  Page : 295--300

Morphine induced subsensitivity to acetylcholine in smooth muscle

PDMV Turlapaty1, S Jayasundar2, S Ramaswamy3 
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Correspondence Address:
PDMV Turlapaty


. Morphine depressed the contractile responses of guineapig ileum to acetylcholine (ACh) in a graded and time-dependent manner. This action of morphine was specific since it did not alter the contractile responses to histamine and potassium chloride. Naloxone, a specific morphine antagonist, failed to prevent morphine-induced subsensitivity to ACh indicating that the action of morphine is not mediated through opiate receptors. High calcium decreased significantly the degree of morphine-induced subsensitivity.


How to cite this article:
Turlapaty P, Jayasundar S, Ramaswamy S. Morphine induced subsensitivity to acetylcholine in smooth muscle.Indian J Pharmacol 1978;10:295-300


How to cite this URL:
Turlapaty P, Jayasundar S, Ramaswamy S. Morphine induced subsensitivity to acetylcholine in smooth muscle. Indian J Pharmacol [serial online] 1978 [cited 2021 Dec 7 ];10:295-300
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1978;volume=10;issue=4;spage=295;epage=300;aulast=Turlapaty;type=0