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Year : 1978  |  Volume : 10  |  Issue : 3  |  Page : 207--213

Excitatory spinal muscarinic cholinoceptors for vasomotor regulation in the dog

VK Srivastava1, RK Srivastava2, G Tayal3, DN Prasad4 
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Correspondence Address:
V K Srivastava


. Role of spinal muscarinic cholinoceptors in vasomotor regulation was studied by observing the effect of m-holinoceptor agonists and antagonists on blood pressure and carotid occlusion response when the drugs were localised within the spinal cord by intrathecal injection in dogs. Intrathecal oxotremorine (1-10 (g) and neostigmine (100-200 (g) raised B. P. and potentiated carotid occlusion response while ethybenztropine (250-l000( (g) and atropine sulphate (g-12 mg) decreased the B. P. and inhibited carotid occlusion response. Furthermore, ethybaztropine prevented the rise in B.P. and potentiation of carotid occlusion response induced by oxotremorine. It is concluded that spinal m-cholinoceptors are excitatory in nature and that at least some of the descending excitatory neurons from supraspinal vasomotor apparatus are possibly m-cholinergic.


How to cite this article:
Srivastava V K, Srivastava R K, Tayal G, Prasad D N. Excitatory spinal muscarinic cholinoceptors for vasomotor regulation in the dog.Indian J Pharmacol 1978;10:207-213


How to cite this URL:
Srivastava V K, Srivastava R K, Tayal G, Prasad D N. Excitatory spinal muscarinic cholinoceptors for vasomotor regulation in the dog. Indian J Pharmacol [serial online] 1978 [cited 2021 May 12 ];10:207-213
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1978;volume=10;issue=3;spage=207;epage=213;aulast=Srivastava;type=0