Indian Journal of Pharmacology Home 

RESEARCH PAPER
[Download PDF]
Year : 1977  |  Volume : 9  |  Issue : 4  |  Page : 253--258

A Comparative trial of some commonly used hypnotics in normal subjects

T Joseph 
 

Correspondence Address:
T Joseph


An attempt has been made to assess under double blind trial, the hypnotic potency of five commonly used hypnotics, in the face of a rapidly filling bladder. All drugs significantly prolonged sleep interval and increased depth of sleep when compared to placebo. When drugs were compared in pairs. there was no significant difference between them except that methaqualone diphenhydramine combination significantly prolonged sleep interval when compared to seconol sodium. The incidence of drowsiness was significant with diphenhydramine (P <0.02) and the occurrence of dreams was very significant with nitrazepum (P <0.001). Head-ache, heaviness of head and dizziness was complained of with methaqualone-diphenhydramine combination (P <0.02). There was no correlation between volume of urine on awakening and sleep interval.


How to cite this article:
Joseph T. A Comparative trial of some commonly used hypnotics in normal subjects.Indian J Pharmacol 1977;9:253-258


How to cite this URL:
Joseph T. A Comparative trial of some commonly used hypnotics in normal subjects. Indian J Pharmacol [serial online] 1977 [cited 2022 Oct 3 ];9:253-258
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1977;volume=9;issue=4;spage=253;epage=258;aulast=Joseph;type=0