| 1 |
Molecular mechanisms involved in the effects of morin in experimental hepatic encephalopathy |
|
|
| Ghada M. Shafey, Engy R. Rashed, Hala F. Zaki, Amina S. Attia, Mona A. El-Ghazaly |
|
| BioFactors. 2022; |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 2 |
System biology-based investigation of Silymarin to trace hepatoprotective effect |
|
|
| Prarambh SR. Dwivedi, Vishal S. Patil, Pukar Khanal, Vishwambhar V. Bhandare, Shailendra Gurav, Darasaguppe R. Harish, B.M. Patil, Subarna Roy |
|
| Computers in Biology and Medicine. 2022; : 105223 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 3 |
A review of nanostructured delivery systems for the encapsulation, protection, and delivery of silymarin: An emerging nutraceutical |
|
|
| Zhiheng Zhang, Xiaojing Li, Shangyuan Sang, David Julian McClements, Long Chen, Jie Long, Aiquan Jiao, Jinpeng Wang, Zhengyu Jin, Chao Qiu |
|
| Food Research International. 2022; : 111314 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 4 |
Effect of Silymarin and Quercetin in a Miniaturized Scaffold in Wistar Rats against Non-alcoholic Fatty Liver Disease |
|
|
| Jaisheela Marry Stephen Robert, Muthukumar Serva Peddha, Alok Kumar Srivastava |
|
| ACS Omega. 2021; 6(32): 20735 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 5 |
The hepatoprotective effect of silibinin after hepatic ischemia/reperfusion in a rat model is confirmed by immunohistochemistry and qRT-PCR |
|
|
| Afrodite Betsou, Maria Lambropoulou, Anastasia-Eirini Georgakopoulou, Nikolaos Kostomitsopoulos, Ourania Konstandi, Konstantinos Anagnostopoulos, Christos Tsalikidis, Constantinos E Simopoulos, Georgia Valsami, Alexandra K Tsaroucha |
|
| Journal of Pharmacy and Pharmacology. 2021; 73(9): 1274 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 6 |
The effects of silymarin on type 2 diabetes mellitus: A systematic review and meta-analysis |
|
|
| Seyed Sina Ravari, Behrouz Talaei, Zahra Gharib |
|
| Obesity Medicine. 2021; 26: 100368 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 7 |
Bioavailability and hepatoprotection enhancement of berberine and its nanoparticles prepared by liquid antisolvent method |
|
|
| Muhammad Umar Khayam Sahibzada, Muhammad Zahoor, Abdul Sadiq, Fazl ur Rehman, Amal M. Al-Mohaimeed, Muhammad Shahid, Sumaira Naz, Riaz Ullah |
|
| Saudi Journal of Biological Sciences. 2021; 28(1): 327 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 8 |
A review on the mechanisms of the effect of silymarin in milk thistle (
Silybum marianum
) on some laboratory animals
|
|
|
| Roshanak Khazaei, Alireza Seidavi, Mehrdad Bouyeh |
|
| Veterinary Medicine and Science. 2021; |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 9 |
Antioxidant and anti-apoptotic prophylactic effect of silymarin against lead-induced hepatorenal toxicity in rats |
|
|
| Mabrouk Attia Abd Eldaim, Eman Ragab Barakat, Mohamed Alkafafy, Samy Ahmed Abd Elaziz |
|
| Environmental Science and Pollution Research. 2021; 28(41): 57997 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 10 |
Changes in Glutathione Content in Liver Diseases: An Update |
|
|
| Mariapia Vairetti, Laura Giuseppina Di Pasqua, Marta Cagna, Plinio Richelmi, Andrea Ferrigno, Clarissa Berardo |
|
| Antioxidants. 2021; 10(3): 364 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 11 |
Emerging Role of Flavonoids as the Treatment of Depression |
|
|
| Arzoo Pannu, Prabodh Chander Sharma, Vijay Kumar Thakur, Ramesh K. Goyal |
|
| Biomolecules. 2021; 11(12): 1825 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 12 |
Fungal Endophytes as Efficient Sources of Plant-Derived Bioactive Compounds and Their Prospective Applications in Natural Product Drug Discovery: Insights, Avenues, and Challenges |
|
|
| Archana Singh, Dheeraj K. Singh, Ravindra N. Kharwar, James F. White, Surendra K. Gond |
|
| Microorganisms. 2021; 9(1): 197 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 13 |
Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity |
|
|
| Im-Sook Song, So-Jeong Nam, Ji-Hyeon Jeon, Soo-Jin Park, Min-Koo Choi |
|
| Pharmaceutics. 2021; 13(5): 628 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 14 |
Characterisation of Preformulation Parameters to Design, Develop and Formulate Silymarin loaded PLGA Nanoparticles for Liver Targeted Drug Delivery |
|
|
| Senthila S, Manojkumar P., Venkatesan P. |
|
| Research Journal of Pharmacy and Technology. 2021; : 5508 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 15 |
Impact of milk thistle (Silybum marianum L.) seeds in fattener diets on pig performance and carcass traits and fatty acid profile and cholesterol of meat, backfat and liver |
|
|
| Eugeniusz R. Grela, Malgorzata Swiatkiewicz, Mariusz Florek, Izabela Wojtaszewska |
|
| Livestock Science. 2020; 239: 104180 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 16 |
Silibinin-hydroxypropyl-ß-cyclodextrin (SLB-HP-ß-CD) complex prevents apoptosis in liver and kidney after hepatic ischemia-reperfusion injury |
|
|
| Alexandra K. Tsaroucha, Georgios N. Korovesis, Georgia Valsami, Maria Lambropoulou, Vasileios Kollaras, Constatinos Anagnostopoulos, Nikolaos Kostomitsopoulos, Eleni Zerbini, Constantinos Simopoulos |
|
| Food and Chemical Toxicology. 2020; 145: 111731 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 17 |
Enhancement of bioavailability and hepatoprotection by silibinin through conversion to nanoparticles prepared by liquid antisolvent method |
|
|
| Muhammad Umar Khayam Sahibzada, Abdul Sadiq, Muhammad Zahoor, Sumera Naz, Muhammad Shahid, Najam Afaq Qureshi |
|
| Arabian Journal of Chemistry. 2020; 13(2): 3682 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 18 |
Polyphenolic rich extract of Oroxylum indicum alleviate ß-glucuronidase activity via down-regulate oxidative stress: Experimental and computational studies |
|
|
| Prateek Pathak, Jurica Novak, Vladislav Naumovich, Maria Grishina, Acharya Balkrishna, Niti Sharma, Vinay Sharma, Vladimir Potemkin, Amita Verma |
|
| Biocatalysis and Agricultural Biotechnology. 2020; 29: 101804 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 19 |
Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation |
|
|
| V. Dhawan, B. Sutariya, A. Lokras, J. Thamm, M. Saraf, U. Warawdekar, A. Fahr, M. Nagarsenker |
|
| International Journal of Pharmaceutics. 2020; 579: 119176 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 20 |
An overview of advanced formulation and nanotechnology-based approaches for solubility and bioavailability enhancement of silymarin |
|
|
| Siddharth S. Kesharwani, Vikas Jain, Surajit Dey, Swagat Sharma, Pooja Mallya, Vadikari Arun Kumar |
|
| Journal of Drug Delivery Science and Technology. 2020; 60: 102021 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 21 |
Insights into hepatic and renal FXR/DDAH-1/eNOS pathway and its role in the potential benefit of rosuvastatin and silymarin in hepatic nephropathy |
|
|
| Yosra M. Magdy, Omnyah A. El-Kharashi, Dalia A.A. El-Waseef, Enas S. Nabih, Abeer A. Abd El Samad |
|
| Experimental and Molecular Pathology. 2018; 105(3): 293 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 22 |
A newer approach in the management of diabetes and reduction of HbA1c level by the use of natural remedies over synthetic drugs |
|
|
| Firoz Khan |
|
| Pharmacy & Pharmacology International Journal. 2018; 6(5) |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 23 |
Evaluating the Safety and Efficacy of Silymarin inß-Thalassemia Patients: A Review |
|
|
| Behjat Al-Sadat Moayedi Esfahani,Nahid Reisi,Milad Mirmoghtadaei |
|
| Hemoglobin. 2015; : 1 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 24 |
Investigation of the Interactions of Silibinin with 2-Hydroxypropyl-ß-cyclodextrin through Biophysical Techniques and Computational Methods |
|
|
| Tahsin F. Kellici,Dimitrios Ntountaniotis,Georgios Leonis,Maria Chatziathanasiadou,Alexandra V. Chatzikonstantinou,Johanna Becker-Baldus,Clemens Glaubitz,Andreas G. Tzakos,Kyriakos Viras,Petros Chatzigeorgiou,Stavros Tzimas,Evangelia Kefala,Georgia Valsami,Helen Archontaki,Manthos G. Papadopoulos,Thomas Mavromoustakos |
|
| Molecular Pharmaceutics. 2015; 12(3): 954 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 25 |
Spherical agglomeration versus solid dispersion as different trials to optimize dissolution and bioactivity of silymarin |
|
|
| G. Balata,H. Shamrool |
|
| Journal of Drug Delivery Science and Technology. 2014; 24(5): 478 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 26 |
Improved dissolution and bioavailability of silymarin delivered by a solid dispersion prepared using supercritical fluids |
|
|
| Gang Yang,Yaping Zhao,Nianping Feng,Yongtai Zhang,Ying Liu,Beilei Dang |
|
| Asian Journal of Pharmaceutical Sciences. 2014; |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 27 |
Silymarin loaded liposomes for hepatic targeting: In vitro evaluation and HepG2 drug uptake |
|
|
| Mohammed Elmowafy,Tapani Viitala,Hany M. Ibrahim,Sherif K. Abu-Elyazid,Ahmed Samy,Alaa Kassem,Marjo Yliperttula |
|
| European Journal of Pharmaceutical Sciences. 2013; 50(2): 161 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 28 |
Tricin 4'-O-(erythro-ß-guaiacylglyceryl) ether and tricin 4'-O-(threo-ß-guaiacylglyceryl) ether isolated from Njavara (Oryza sativa L. var. Njavara), induce apoptosis in multiple tumor cells by mitochondrial pathway |
|
|
| Smitha Mohanlal,Sathish Kumar Maney,Thankayyan Retnabai Santhoshkumar,Ananthasankaran Jayalekshmy |
|
| Journal of Natural Medicines. 2013; 67(3): 528 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 29 |
Effects of silymarin on the pharmacokinetics of atorvastatin in diabetic rats |
|
|
| Hassan Malekinejad,Shirin Rokhsartalab-Azar,Sepideh Hassani-Dizaj,Shahin Alizadeh-Fanalou,Aysa Rezabakhsh,Amir Amniattalab |
|
| European Journal of Drug Metabolism and Pharmacokinetics. 2013; |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 30 |
A pair of chiral flavonolignans as novel anti-cyanobacterial allelochemicals derived from barley straw (Hordeum vulgare): characterization and comparison of their anti-cyanobacterial activities |
|
|
| Xi Xiao,Haomin Huang,Zhiwei Ge,Trine B. Rounge,Jiyan Shi,Xinhua Xu,Ruobing Li,Yingxu Chen |
|
| Environmental Microbiology. 2013; : n/a |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 31 |
Neuroprotective Potential of Silymarin against CNS Disorders: Insight into the Pathways and Molecular Mechanisms of Action |
|
|
| Anupom Borah,Rajib Paul,Sabanum Choudhury,Amarendranath Choudhury,Bornalee Bhuyan,Anupam Das Talukdar,Manabendra Dutta Choudhury,Kochupurackal P Mohanakumar |
|
| CNS Neuroscience & Therapeutics. 2013; 19(11): 847 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 32 |
Short Communication: Effect of silymarin (Silybum marianum) treatment on prolactin concentrations in cyclic sows |
|
|
| F. Loisel,H. Quesnel,C. Farmer |
|
| Canadian Journal of Animal Science. 2013; 93(2): 227 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 33 |
Silibinin modulates the NF-?b pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women |
|
|
| Vanessa S. Innocenti Giorgi,Maria Terezinha S. Peracoli,José C. Peracoli,Steven S. Witkin,Camila F. Bannwart-Castro |
|
| Journal of Reproductive Immunology. 2012; 95(1-2): 67 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 34 |
Oil based nanocarrier for improved oral delivery of silymarin: In vitro and in vivo studies |
|
|
| Rabea Parveen, Sanjula Baboota, Javed Ali, Alka Ahuja, Suruchi S. Vasudev, Sayeed Ahmad |
|
| International Journal of Pharmaceutics. 2011; |
|
| [HTML Full text] [Google Scholar] [DOI] |
|
| 35 |
Antihypertensive effect of Silymarin on DOCA salt induced hypertension in unilateral nephrectomized rats |
|
|
| G. B. Jadhav, C. D. Upasani |
|
| Oriental Pharmacy and Experimental Medicine. 2011; |
|
| [HTML Full text] [Google Scholar] [DOI] |
|
| 36 |
Oil based nanocarrier for improved oral delivery of silymarin: In vitro and in vivo studies |
|
|
| Parveen, R., Baboota, S., Ali, J., Ahuja, A., Vasudev, S.S., Ahmad, S. |
|
| International Journal of Pharmaceutics. 2011; 413(1-2): 245-253 |
|
| [Pubmed] [Google Scholar] |
|
| 37 |
Rumen degradability and whole tract digestibility of flavonolignans from milk thistle (Silybum marianum) fruit expeller in dairy cows |
|
|
| Křížová, L., Watzková, J., Třináctý, J., Richter, M., Buchta, M. |
|
| Czech Journal of Animal Science. 2011; 56(6): 269-278 |
|
| [Pubmed] [Google Scholar] |
|
| 38 |
Downregulation of nuclear factor-kappa B (NF-κB) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis |
|
|
| Bannwart, C.F., Nakaira-Takahagi, E., Golim, M.A., de Medeiros, L.T.L., Romão, M., Weel, I.C., Serrão Peraçoli, M.T. |
|
| Life Sciences. 2010; 86(23-24): 880-886 |
|
| [Pubmed] [Google Scholar] |
|
| 39 |
Stability-indicating HPTLC method for quantitative estimation of silybin in bulk drug and pharmaceutical dosage form |
|
|
| Parveen, R., Ahmad, S., Baboota, S., Ali, J., Alka, A. |
|
| Biomedical Chromatography. 2010; 24(6): 639-647 |
|
| [Pubmed] [Google Scholar] |
|
| 40 |
Downregulation of nuclear factor-kappa B (NF-κB) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis |
|
|
| Camila Ferreira Bannwart, Erika Nakaira-Takahagi, Marjorie Assis Golim, Leonardo Teixeira Lopes de Medeiros, Mariana Romão, Ingrid Cristina Weel, Maria Terezinha Serrão Peraçoli |
|
| Life Sciences. 2010; 86(23-24): 880 |
|
| [HTML Full text] [Google Scholar] [DOI] |
|
| 41 |
Silymarin-solid dispersions: Characterization and influence of preparation methods on dissolution |
|
|
| Dalwadi Sonali, Soni Tejal, Thakkar Vaishali, Gandhi Tejal |
|
| Acta Pharmaceutica. 2010; 60(4): 427 |
|
| [HTML Full text] [Google Scholar] [DOI] |
|
| 42 |
Protective effect of silymarin in streptozotocin-induced diabetic dyslipidaemia in rats |
|
|
| Manju Sharma, K.K. Pillai, Tarique Anwer, Abul Kalam Najmi, Syed Ehtaishamul Haque, Yasmin Sultana |
|
| Oriental Pharmacy and Experimental Medicine. 2010; 10(3): 165 |
|
| [HTML Full text] [Google Scholar] [DOI] |
|
| 43 |
Hepatoprotective Activity of Polyherbal Formulation (Normeta®) in Oxidative Stress Induced by Alcohol, Polyunsaturated Fatty Acids and Iron in Rats |
|
|
| Shilpa N. Patere,Madhusudan N. Saraf,Anuradha S. Majumdar |
|
| Basic & Clinical Pharmacology & Toxicology. 2009; 105(3): 173 |
|
| [Pubmed] [Google Scholar] [DOI] |
|
| 44 |
Hepatoprotective activity of hydroalcoholic extract of leaves of Alocasia indica (Linn.) |
|
|
| Mulla, W.A., Salunkhe, V.R., Bhise, S.B. |
|
| Indian Journal of Experimental Biology. 2009; 47(10): 816-821 |
|
| [Pubmed] [Google Scholar] |
|
| 45 |
Hepatoprotective activity of polyherbal formulation (Normeta®) in oxidative stress induced by alcohol, polyunsaturated fatty acids and iron in rats |
|
|
| Patere, S.N., Saraf, M.N., Majumdar, A.S. |
|
| Basic and Clinical Pharmacology and Toxicology. 2009; 105(3): 173-180 |
|
| [Pubmed] [Google Scholar] |
|
| 46 |
Natural anti-HCV agents |
|
|
| Fan, H., Starks, C.M., Hughey, H., Eldridge, G.R., Hu, J.-F. |
|
| Drugs of the Future. 2009; 34(3): 223-236 |
|
| [Pubmed] [Google Scholar] |
|
| 47 |
Stability-indicating HPTLC method for quantitative estimation of silybin in bulk drug and pharmaceutical dosage form |
|
|
| Rabea Parveen,Sayeed Ahmad,Sanjula Baboota,Javed Ali,Ahuja Alka |
|
| Biomedical Chromatography. 2009; : n/a |
|
| [Pubmed] [Google Scholar] [DOI] |
|
