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 Table of Contents    
LETTER TO THE EDITOR
Year : 2023  |  Volume : 55  |  Issue : 3  |  Page : 198-199
 

Concurrent administration of COVID-19 vaccine and seasonal influenza vaccine: No increased estimated vaccine-related mortality rate


1 Private Academic Consultant, Bangkok, Thailand
2 Department of Biological Science, Joseph Ayobabalola University, Ikeji-Arakeji, Osun State, Nigeria

Date of Submission21-Jan-2023
Date of Decision21-Mar-2023
Date of Acceptance13-Jul-2023
Date of Web Publication01-Aug-2023

Correspondence Address:
Pathum Sookaromdee
Private Academic Consultant, 111 Bangkok, 122 Bangkok, 103300
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijp.ijp_47_23

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How to cite this article:
Sookaromdee P, Wiwanitkit V. Concurrent administration of COVID-19 vaccine and seasonal influenza vaccine: No increased estimated vaccine-related mortality rate. Indian J Pharmacol 2023;55:198-9

How to cite this URL:
Sookaromdee P, Wiwanitkit V. Concurrent administration of COVID-19 vaccine and seasonal influenza vaccine: No increased estimated vaccine-related mortality rate. Indian J Pharmacol [serial online] 2023 [cited 2023 Dec 4];55:198-9. Available from: https://www.ijp-online.com/text.asp?2023/55/3/198/382572




Dear Editor,

According to the clinical recommendation, the COVID-19 vaccine and the influenza (flu) vaccination (dual immunization) may be given at the same time. The findings suggest that dual immunization may be an effective method for lowering the incidence of infectious respiratory diseases.[1] A report by Baj et al. demonstrates the effectiveness and safety of the combination of COVID-19 and flu immunization in 63 of the investigations.[2] Adverse events and anti-spike antibody levels remained unchanged.[1] The authors of this study provide more information on 42 instances of concomitant COVID-19 and seasonal flu vaccination administration. According to regional standards, contemporaneous dual immunizations were administered in each case. There is no negative impact, according to surveillance of the reported adverse event.[2],[3]

The aforementioned publications, however, only cover a very small number of observations, and there is still no precise information on the incidence rate of negative effects in the context of the simultaneous administration of the COVID-19 vaccine and the seasonal influenza vaccination. The serious side effects of any vaccine are a major source of worry. The most regrettable adverse effect is vaccine-related death, although it can still happen with every vaccination. In essence, the incidence rate of side effects varies depending on the vaccine, including the COVID-19 vaccine and the seasonal influenza vaccine. The combined possibility of a negative outcome can be anticipated when the two vaccines are administered jointly. Both vaccines, nevertheless, run the risk of having negative side effects. The final anticipated rate of adverse effect in the case of concurrent administration of the COVID-19 vaccine and the seasonal influenza vaccine will be equal to “chance of adverse fatal effect due to COVID-19 vaccine + change of adverse fatal effect due to influenza vaccine − chance of jointed probability due to both vaccines,” according to a mathematical model-based approach based on set theory. The estimated rate of side effects linked to the simultaneous administration of the COVID-19 vaccination and the seasonal influenza vaccine is predicted using this model.

The risk of an adverse reaction to the COVID-19 vaccine is 8.19/100,000 doses, whereas the risk of a serious reaction to the influenza vaccination is 0/100,000 doses disseminated.[4],[5] The probability of both vaccines working together is predicted to be 0/100,000 doses. The estimated rate of serious adverse effects in the case of concurrent administration of COVID-19 immunization and seasonal influenza vaccine is 8.19/100,000 doses, which is only nonsignificant for nondual COVID-19 vaccine administration. As a result, it can speak to the efficacy and safety of administering the COVID-19 vaccine and the seasonal influenza immunization at the same time in clinical settings.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Xie Z, Hamadi HY, Mainous AG, Hong YR. Association of dual COVID-19 and seasonal influenza vaccination with COVID-19 infection and disease severity. Vaccine 2023;41:875-8.  Back to cited text no. 1
    
2.
Baj A, Gasperina DD, Focosi D, Forlani G, Ferrante FD, Novazzi F, et al. Safety and immunogenicity of synchronous COVID-19 and influenza vaccination. J Clin Virol Plus 2022;2:100082.  Back to cited text no. 2
    
3.
Nawwar AA, Searle J, Lyburn ID. Bilateral avid axillary nodes on FDG PET/CT due to concurrent booster COVID-19 immunization and seasonal influenza vaccination. Clin Nucl Med 2022;47:712-3.  Back to cited text no. 3
    
4.
Silva RB, Silva TP, Sato AP, Lana FC, Gusmão JD, Souza JF, et al. Adverse events following immunization against SARS-CoV-2 (COVID-19) in the state of Minas Gerais. Rev Saude Publica 2021;55:66.  Back to cited text no. 4
    
5.
Lawrence G, Boyd I, McIntyre P, Isaacs D. Surveillance of adverse events following immunisation: Australia 2002 to 2003. Commun Dis Intell Q Rep 2004;28:324-38.  Back to cited text no. 5
    




 

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