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| RESEARCH ARTICLE |
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| Year : 2023 | Volume
: 55
| Issue : 2 | Page : 76-88 |
Variation in normative values of major clinical biochemistry analytes in healthy reproductive-age women in India: A subset of data from a National Indian Council of Medical Research-Polycystic Ovary Syndrome task force study
Mohd Ashraf Ganie1, Subhankar Chowdhury2, Vanita Suri3, Beena Nitin Joshi4, Prasanta Kumar Bhattacharya5, Sarita Agarwal6, Neena Malhotra7, Rakesh Sahay8, PK Jabbar9, Roya Rozati10, Amlin Shukla11, Haroon Rashid12, Rohina Bashir12, Imtiyaz Wani12, Abhilash Nair9, Taruna Katyal Arora11, Bharati Kulkarni11
1 Department of Endocrinology, Sher-i Kashmir Institute of Medical Sciences, Jammu and Kashmir, India
2 Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education and Research, West Bengal, India
3 Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
4 Department of Operational Research, National Institute for Research in Reproductive and Child Health (NIRRCH), Mumbai, India
5 Department of General Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, India
6 Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Raipur, India
7 All India Institute of Medical Sciences, New Delhi, India
8 Department of Endocrinology, Osmania Medical College and Aster Prime Hospital, Hyderabad, India
9 Department of Endocrinology, Professor and Head, Government Medical College, Thiruvananthapuram, Kerala, India
10 Department of Obstetrics and Gynaecology, Maternal Health and Research Institute, Telangana, India
11 Indian Council of Medical Research, New Delhi, India
12 Department of Clinical Research, Sher-i Kashmir Institute Of Medical Sciences, Jammu and Kashmir, India
Correspondence Address:
Mohd Ashraf Ganie
Sher-i Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijp.ijp_694_22
OBJECTIVES: Clinical biochemistry reference intervals (RIs) play a crucial role in interpreting patient test results and making informed clinical decisions. Using data from an ongoing Indian Council of Medical Research-National task force study on healthy women, normative ranges for commonly analyzed biochemical analytes were established.
MATERIALS AND METHODS: A total of 13,181 women of reproductive age (18–40 years) were recruited from different urban and rural regions of the country, of which 9898 women signed an informed consent were included. Among these, women having features of hyperandrogenism, menstrual cycle irregularities, and comorbidities were excluded. RIs of 22 analytes were computed in the remaining 938 women controls. To estimate the 95% range of the reference distribution, the limits of the 2.5th percentile and the 97.5th percentile were used in the study.
RESULTS: Mean ± standard deviation of age and body mass index of participants was 30.12 ± 6.32 years and 22.8 ± 3.36 kg/m2 respectively. Centiles (2.5th–97.5th) of liver function parameters, lipid parameters, glycaemic parameters, and renal parameters are presented. No significant difference in analytes was observed in relation to the area of residence, and age groups except in albumin (P = 0.03). The distribution of most of the parameters was consistent with the various RI studies conducted in India as well as other countries.
CONCLUSION: This is the first study generating biochemical RIs data among a large representative sample of healthy reproductive-age women recruited using a robust design across the country. The resource may serve as a reference range for common biochemical analytes for future in this age group.
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