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Year : 2023  |  Volume : 55  |  Issue : 1  |  Page : 34-42

Nephroprotective potential of syringic acid in experimental diabetic nephropathy: Focus on oxidative stress and autophagy

1 Department of Pharmacology and Toxicology, NIPER, Hyderabad, Balanagar, Telangana, India; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Sweden
2 Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada
3 Chemical Biology Unit, Institute of Nano Science and Technology, Mohali, Punjab, India
4 College of Pharmacy and Pharmaceutical Science Florida A and M University Tallahassee, FL, USA
5 Department of Neurosurgery, University of Wisconsin-Madison, Madison, WI, USA
6 Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) Kolkata, Chunilal Bhawan, Maniktala Main Road, Kolkata; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) SAS Nagar, Mohali, Punjab, India

Correspondence Address:
Ashutosh Kumar
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) SAS Nagar, Mohali Bypass, Sector 67, Sahibzada Ajit Singh Nagar, Punjab - 160062
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijp.ijp_671_22

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BACKGROUND: Diabetic nephropathy (DN) is a chronic hyperglycemic manifestation of microvascular damage in the kidneys. Widespread research in this area suggests the involvement of perturbed redox homeostasis and autophagy in renal cells phrase- promote the progression of DN. MATERIALS AND METHODS: Reframed sentences-The present study investigates the pharmacological effect of Syringic acid (SYA), in streptozotocin (STZ, 55 mg/kg, i.p) induced diabetic nephropathy model and in high glucose (30 mM) challenged rat renal epithelial cells (NRK 52E) cells with a focus on oxidative stress and autophagy mechanisms. RESULTS: Both in vivo and in vitro experimental data revealed elevated oxidative stress markers along with compromised levels of nuclear factor erythroid 2-related factor 2 (Nrf2), a pivotal cellular redox-regulated transcription factor in renal cells upon glycemic stress. Elevated blood glucose also reduced the autophagy process as indicated by low expression of light chain (LC) 3-IIB in diabetic kidney and in NRK 52E cells subjected to excess glucose. SYA (25 and 50 mg/kg, p.o.) administration for 4 weeks to diabetic rats, Reframed sentence-preserved the renal function as evidenced by reduced serum creatinine levels as well as improved urine creatinine and urea levles as compared to non treated diabetic animals. At the molecular level, SYA improved renal expression of Nrf2 and autophagy-related proteins (Atg5, Atg3, and Atg7) in diabetic rats. Similarly, SYA (10 and 20 μM) co-treatment in high glucose-treated NRK 52E cells displayed increased levels of Nrf2 and autophagy induction. CONCLUSION: Results from this study signify the renoprotective effect of SYA and highlight the modulation of oxidative stress and autophagy mechanisms to mitigate diabetic kidney disease.


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