| EXPERIMENTAL RESEARCH ARTICLE
|Year : 2022 | Volume
| Issue : 3 | Page : 194-197
Influence of trazodone on the pharmacodynamics and pharmacokinetics of pioglitazone
Bhupalam Pradeepkumar1, Narayana Goruntla2, Haranath Chinthaginjala3, K Somasekhar Reddy1, Abdul Ahad3, A Sudheer1, M Raghavendra4
1 Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (Autonomous), Anantapur, Andhra Pradesh, India
2 Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical Education and Research (Autonomous), Anantapur, Andhra Pradesh, India
3 Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research (Autonomous), Anantapur, Andhra Pradesh, India
4 Department of Pharmacology, CMR College of Pharmacy, Hyderabad, Telangana, India
BACKGROUND: These days, poly pharmacy is very common for the treatment of multiple diseases and majority of drugs were metabolized with CYP 450 enzymes. Diabetes mellitus is such a disorder, which requires continuous therapy for the control of blood glucose concentration. Depression was quite common in diabetic patients. Therefore, multiple drugs required to treat diabetes mellitus and depression. Simultaneous administration of these drugs leads to drug interaction. Pioglitazone and trazodone metabolized by CYP3A4 enzymes which may lead to potential drug interaction.
OBJECTIVES: This study aimed to find the influence of trazodone on the pharmacokinetics & pharmacodynamics of pioglitazone in normal & diabetic rats, also on rabbits and subsequently effectiveness and safety of the combination was evaluated.
METHODS AND MATERIAL: Blood glucose concentration was determined by Glucose oxidase/peroxidase method in normal and diabetic rats. Diabetes was induced with Streptozotocin at a dose of 55 mg/kg body weight. Serum pioglitazone concentration was estimated by high performance liquid chromatography method for pharmacokinetic data. The values were expressed as Mean ± Standard Error Mean (SEM), GraphPad Prism 3.0 (San Diego, California, USA) software was used to express the data. Student's paired 't' test was used to determine the significance.
RESULTS: Pioglitazone produces hypoglycaemia in normal rats with a maximum decrease of 36.78 % ± 0.81 at 3 hours interval and anti-hyperglycaemic activity in diabetic rats with maximum reduction of 45.13 % ± 1.52 at 2 hours interval. Trazodone altered the pharmacokinetics of pioglitazone and improved the pioglitazone hypoglycaemic effect.
CONCLUSION: Trazodone apparently produced pharmacokinetic interaction with pioglitazone which might be by attenuating the metabolism of pioglitazone. Therefore, care should be taken in simultaneous therapy with pioglitazone and trazodone.
Dr. Bhupalam Pradeepkumar
Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (Autonomous), Anantapur - 515 721, Andhra Pradesh
Source of Support: None, Conflict of Interest: None
[FULL TEXT] [PDF]*