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 EXPERIMENTAL RESEARCH ARTICLE
Year : 2022  |  Volume : 54  |  Issue : 2  |  Page : 102-109

Evaluation of anti-amnesic effect of Conyza bonariensis in rats


1 Department of Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Guwahati, Assam, India
2 Department of Veterinary Biochemistry, College of Veterinary Science, Assam Agricultural University, Guwahati, Assam, India
3 Department of Veterinary Pathology, College of Veterinary Science, Assam Agricultural University, Guwahati, Assam, India
4 Public Health, College of Veterinary Science, Assam Agricultural University, Guwahati, Assam, India
5 Department of Agronomy, Assam Agricultural University, Jorhat, Assam, India
6 Department of Chemistry, Drug Discovery Lab, Annamalai University, Chidambaram, Tamil Nadu, India

Correspondence Address:
Dr. Beenita Saikia
Department of Pharmacology, College of Veterinary Science, Khanapara, Guwahati - 781 022, Assam
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijp.ijp_201_19

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OBJECTIVE: Conyza bonariensis is an ornamental medicinal weed. This experiment was planned to explore the outcome of petroleum ether extract of C. bonariensis (PECB) leaves on scopolamine-induced amnesia in rats. MATERIALS AND METHODS: For impairing memory, 0.4 mg/kg (i. p.) of scopolamine was given. Fifty to 200 mg/kg of PECB was fed orally to rats and 3 mg/kg (i. p.) of tacrine was given as a standard drug. Anti-amnesic property was evaluated in Barnes maze using ANY-maze software. Following a behavioral study, acetylcholinesterase (AChE), β-amyloid1-41, antioxidant enzymes, and cytokine levels were measured. Furthermore, reverse transcription–polymerase chain reaction was done for expression of the marker genes such as AChE, Nrf2, NF-κB, PP2A, and HO-1, whereas BDNF, TrkB, caspase-3, and Bax were measured by Western blotting. RESULTS: PECB and tacrine significantly improved memory dysfunction by decreasing escape latency in Barnes maze. At the highest dose, treatment with PECB altered the scopolamine-induced hyperactivation of AChE and β-amyloid1-41 activity. PECB elevated the levels of superoxide dismutase, glutathione, and catalase and decreased lipid peroxidation and nitric oxide dose dependently. PECB attenuated scopolamine-induced increase of tumor necrosis factor-α and interleukin (IL)-1β concentrations in the hippocampus with reversed diminished IL-10 level toward normal in the brain. Nrf2, HO-1, PP2A, BDNF, and TrkB were significantly upregulated with downregulation of AChE, NF-κB, Tau, Bax, and caspase-3. Different components such as beta-amyrin and alpha-amyrin were isolated from leaves of the plant. CONCLUSION: The results indicated that PECB might be a potential curative drug for the treatment of cognitive impairment.






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