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| RESEARCH ARTICLE
|Year : 2022 | Volume
| Issue : 1 | Page : 7-12
Efficacy and acceptability of pomegranate effervescent granules in patients suffering from acid peptic disorders
Poonam Ashish Gupte1, Madhavi Prabhakar Mahajan2, Minakshi Subhash Revadkar Kole3, Ajitkumar Harichand Mandlecha4, Pratima Arun Tatke5, Vikram Andrew Naharwar6, Supriya Sudhakar Bhalerao1
1 Department of Obesity Diabetes Laboratory, Interactive Research School For Health Affairs, Bharati Vidyapeeth (Deemed to be) University, Pune, Maharashtra, India
2 Department of Kayachikitsa, College of Ayurved, Bharati Vidyapeeth (Deemed to be) University, Pune, Maharashtra, India
3 Department of Kayachikitsa, M. A. Podar Ayurved Hospital, Mumbai, Maharashtra, India
4 Medical Director, Vishwanand Kendra, Pune, Maharashtra, India
5 Department of Pharmaceutical Chemistry, C.U. Shah College of Pharmacy, S.N.D.T. Women's University, Mumbai, Maharashtra, India
6 Amsar Goa Pvt., Ltd., S 12, Colvale Industrial Estate, Bardez, Goa, India
CONTEXT: Acid peptic disorders.
AIMS: This study aimed to assess the efficacy and acceptability of pomegranate effervescent granules (PEGs) in dyspeptic patients.
SETTINGS AND DESIGN: It was a single-arm, open-labeled prospective multicentric clinical study, done at 3 centers: Vishwanand Kendra, Pune; Bharati Ayurved Hospital, Bharati Vidyapeeth, Pune, and M. A. Podar Medical Ayurved Hospital, Mumbai. The co-ordinating site was Interactive Research School for Health Affairs, Bharati Vidyapeeth, Pune.
MATERIALS AND METHODS: The granules, prepared from peel extract of pomegranate, were made available in sachets of 2.5 g with dose of, 1 sachet dissolved in 200 ml (1 cup) of water, twice a day after meals for 28 days. Gastrointestinal Symptom Rating Scale (GSRS) scores to assess symptoms of acid peptic disorders at day 0, 15, and 29 along with the taste of formulation were the main study outcomes.
STATISTICAL ANALYSIS USED: Parametric data, presented as mean ± standard deviation, were analyzed using paired t-test, while nonparametric data presented as median (range) was analyzed using Wilcoxon rank-sum test. Categorical data were analyzed using Chi-square test.
RESULTS: The median GSRS score reduced from 14 on day 0–10 and then 5 on day 15 and day 29, respectively, with statistical significance. The formulation was found to taste good by ~80% of patients, while ~20% reported it to be palatable and none found it to be bad in taste.
CONCLUSION: PEGs proved to be palatable, patient-friendly, safe, and efficacious in resolving symptoms of dyspepsia in acid peptic disorders.
CTRI Registration: The trial was registered retrospectively in the Clinical Registry of India [CTRI/2017/07/008999].
Dr. Supriya Sudhakar Bhalerao
Interactive Research School for Health Affairs, Bharati Vidyapeeth (Deemed to be) University, Pune Satara Road, Dhankawdi, Katraj, Pune - 411 043, Maharashtra
Source of Support: None, Conflict of Interest: None
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