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 DRUG WATCH
Year : 2021  |  Volume : 53  |  Issue : 2  |  Page : 157-159

Liposomal amphotericin B-induced reversible ototoxicity in a patient with disseminated histoplasmosis


1 Department of Medicine PGIMER and Dr. RML Hospital, New Delhi, India
2 Department of Pathology, PGIMER and Dr. RML Hospital, New Delhi, India

Correspondence Address:
Dr. Ramadoss Ramu
Department of Medicine, PGIMER and Dr. RML Hospital, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.316948

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Amphotericin B (AmB) is a polyene antifungal agent used widely for systemic fungal infections. Infusion-related side effects, nephrotoxicity, and dyselectrolytemia are well-known adverse effects with the use of this drug. Liposomal preparation of AmB has less adverse events. However, ototoxicity due to AmB is scarcely mentioned in the literature. We report a case of disseminated histoplasmosis who was treated with liposomal amphotericin B (LAmB) and developed hearing loss during the treatment, which recovered after discontinuing the drug. This is a rare adverse effect of LAmB and reported only once from India, to the best of our knowledge.






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