IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1509 
Small font sizeDefault font sizeIncrease font size
Navigate Here
  Search
 
  
Resource Links
   Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
   Article in PDF (542 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)

 
In This Article
   References
   Article Figures
   Article Tables

 Article Access Statistics
    Viewed122    
    Printed0    
    Emailed0    
    PDF Downloaded3    
    Comments [Add]    

Recommend this journal

 


 
 Table of Contents    
LETTER TO THE EDITOR
Year : 2021  |  Volume : 53  |  Issue : 1  |  Page : 78-79
 

Implication of nanotechnology-based approaches to combat SARS-CoV-2 infection


1 Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran
2 Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences; Razi Pharmed-Far'avaran Pharmaceutical Inc., Shiraz, Iran

Date of Submission01-Sep-2020
Date of Decision07-Nov-2020
Date of Acceptance17-Mar-2021
Date of Web Publication28-Apr-2021

Correspondence Address:
Dr. Mohsen Salmanpour
Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz; Razi Pharmed-Far'avaran Pharmaceutical Inc., Shiraz
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijp.ijp_857_20

Rights and Permissions



How to cite this article:
Heidari M, Salmanpour M, Tamaddon AM. Implication of nanotechnology-based approaches to combat SARS-CoV-2 infection. Indian J Pharmacol 2021;53:78-9

How to cite this URL:
Heidari M, Salmanpour M, Tamaddon AM. Implication of nanotechnology-based approaches to combat SARS-CoV-2 infection. Indian J Pharmacol [serial online] 2021 [cited 2021 May 15];53:78-9. Available from: https://www.ijp-online.com/text.asp?2021/53/1/78/315088




Sir,

Today, achieving fast and efficient treatment strategies for the COVID-19 infection is vital to manage this global health-threatening pandemic. For this purpose, we attempted to introduce nanotechnology-based approaches for improving the efficacy of the antiviral agents in treatment of severe acute respiratory syndrome-coronavirus (SARS-CoV) infections.

Owing to the role of nanotechnology to improve the physicochemical, pharmacokinetic, and pharmacodynamic issues of therapeutic agents, this strategy can be used in the treatment of many types of diseases such as viral infections, as reported in [Table 1].
Table 1: Antiviral drug candidates against severe acute respiratory syndrome-coronavirus-2 infection currently in clinical trial and their nanoformulation studies

Click here to view


Nanoparticles have made a major breakthrough in treatment of different viral infections due to their size (1–100 nm) and their capability to load antiviral agents. [Table 1] presents the advantages of numerous nanoformulations with potential antiviral activity against SARS-CoVs. As shown, oral administration of lopinavir-loaded solid lipid nanoparticles in Wistar rats infected with HIV showed the pharmacokinetic parameters (Cmax, Tmax, mean residence time, area under the curve, oral bioavailability, distribution profile, and lymph accumulation) that were improved significantly in comparison with free lopinavir.[1] In other studies, selenium nanoparticles loaded with ribavirin[2] or arbidol[4] showed antiviral activity in MDCK cells infected with H1N1, which were significantly higher than their free forms through targeting caspase-3 mediated cell apoptosis.[2],[4] In addition, investigating the polyionic complex of poly (lactic acid) and arabinogalactan-poly (L-glutamic acid) as a nanocarrier for delivery of ribavirin in hepatitis C murine model revealed that the ribavirin-loaded nanoparticles significantly increased drug accumulation in the infected cells with less anemia side effects compared with the free drug.[3]

Polymeric drug delivery systems as polymer-drug conjugation and drug-loaded polymer nanoparticles are the navel approaches employed by the researcher. PEG, poly (2-alkyl-2-oxazoline) with methyl and ethyl alkyl substitution,[5] and poly (lactic-co-glycolic) acid (PLGA) are the Food and Drug Administration (FDA)-approved polymers which can be widely used for this purpose to get fast and more efficacy of small antiviral agents by improving their pharmacokinetic. For example, remdesivir, an FDA-approved anti-SARS-CoV-2 agent, with a very low half-life (less than an hour) can be conjugated to living poly (2-ethyl-2-oxazoline) [Figure 1] or can be incorporated to PLGA nanoparticles to improve its pharmacokinetic by prolonging blood remaining through enhancing remdesivir solubility.
Figure 1: Schematic conjugation of remdesivir to synthesized living poly (2-ethyl-2-oxazoline)

Click here to view


Conclusively, the treatment of COVID-19 requires fast and effective strategies based on current antiviral therapeutic agents. As it is explained about the possible therapeutic improvements of antiviral nanoformulations, it is strongly suggested that the faster and more efficient treatments of SARS-CoV-2 infection may be achieved by clinical studying the nanoforms of drug candidates.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Ravi PR, Vats R, Dalal V, Murthy AN. A hybrid design to optimize preparation of lopinavir loaded solid lipid nanoparticles and comparative pharmacokinetic evaluation with marketed lopinavir/ritonavir coformulation. J Pharm Pharmacol 2014;66:912-26.  Back to cited text no. 1
    
2.
Lin Z, Li Y, Gong G, Xia Y, Wang C, Chen Y, et al. Restriction of H1N1 influenza virus infection by selenium nanoparticles loaded with ribavirin via resisting caspase-3 apoptotic pathway. Int J Nanomedicine 2018;13:5787-97.  Back to cited text no. 2
    
3.
Kaneko K, Ishihara T. Development of liver-specific ribavirin-loaded nanoparticles with reduced cytotoxicity. Cogent Medicine. 2017;4:1418133.  Back to cited text no. 3
    
4.
Li Y, Lin Z, Gong G, Guo M, Xu T, Wang C, et al. Inhibition of H1N1 influenza virus-induced apoptosis by selenium nanoparticles functionalized with arbidol through ROS-mediated signaling pathways. J Mater Chem B 2019;7:4252-62.  Back to cited text no. 4
    
5.
Salmanpour M, Tamaddon A, Yousefi G, Mohammadi-Samani S. “Grafting-from” synthesis and characterization of poly (2-ethyl-2-oxazoline)-b-poly (benzyl L-glutamate) micellar nanoparticles for potential biomedical applications. Bioimpacts 2017;7:155-66.  Back to cited text no. 5
    


    Figures

  [Figure 1]
 
 
    Tables

  [Table 1]



 

Top
Print this article  Email this article
 

    

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow