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Year : 2021  |  Volume : 53  |  Issue : 1  |  Page : 2-5

Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation

1 Department of Clinical Pharmacy and Pharm. D, Vaagdevi College of Pharmacy, Kakatiya University, MGM Hospital, Warangal, Telangana, India
2 Department of Psychiatry, Kakatiya Medical College, MGM Hospital, Warangal, Telangana, India

Correspondence Address:
Dr. Venkateshwarlu Eggadi
Department of Clinical Pharmacy and Pharm. D, Vaagdevi College of Pharmacy, Kakatiya University, MGM Hospital, Warangal - 506 001, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijp.IJP_114_20

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AIM: The current work establishes an easy, reliable technique for the estimation of serum Olanzapine concentration which correlates it clinically. SUBJECTS AND METHODS: The work was agreed in 61 schizophrenic patients who were on olanzapine. Serum drug amount was estimated by normal-phase high-performance liquid chromatography and brief psychiatry rating scale was used to determine disease progression. RESULTS: Samples provided 61 patients, 40 were under sub-therapeutic range, 18 were under therapeutic range and 3 were above the therapeutic range. CONCLUSION: Therapeutic drug monitoring must be a part of clinical practice in psychiatric hospitals for optimizing the dose of an individual patient along with the correlation of serum concentration with the clinical assessment scales.


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