IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 158 
Small font sizeDefault font sizeIncrease font size
Navigate Here
  Search
 
  
Resource Links
   Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
   Article in PDF (490 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)

 
In This Article
   References
   Article Figures

 Article Access Statistics
    Viewed1132    
    Printed22    
    Emailed0    
    PDF Downloaded46    
    Comments [Add]    

Recommend this journal

 


 
 Table of Contents    
LETTER TO THE EDITOR
Year : 2020  |  Volume : 52  |  Issue : 5  |  Page : 441-442
 

Are multiple sclerosis therapies safe in severe acute respiratory syndrome coronavirus 2 times?


1 Department of Pharmaceutical, Usl Umbria 1, Perugia, Italy
2 Department of Clinical Pathology, Asur Marche, Macerata, Italy

Date of Submission23-May-2020
Date of Decision20-Jul-2020
Date of Acceptance05-Oct-2020
Date of Web Publication5-Dec-2020

Correspondence Address:
Dr. Francesco Ferrara
Department of Pharmaceutical, Usl Umbria 1, Perugia
Italy
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijp.IJP_417_20

Rights and Permissions



How to cite this article:
Ferrara F, Porta RL, Santilli P, D'Aiuto V, Vitiello A. Are multiple sclerosis therapies safe in severe acute respiratory syndrome coronavirus 2 times?. Indian J Pharmacol 2020;52:441-2

How to cite this URL:
Ferrara F, Porta RL, Santilli P, D'Aiuto V, Vitiello A. Are multiple sclerosis therapies safe in severe acute respiratory syndrome coronavirus 2 times?. Indian J Pharmacol [serial online] 2020 [cited 2021 Nov 28];52:441-2. Available from: https://www.ijp-online.com/text.asp?2020/52/5/441/302502




Sir,

Following the activation of the cytokinic cascade due to the severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) virus and the accumulation of fibrotic tissue, patients with multiple sclerosis face an additional complication to avoid worsening their disease.[1],[2] There are many drugs approved for the treatment of MS that lead to good disease control and high patient adherence and compliance. Unfortunately, however, these drugs are not free from serious adverse reactions which in some cases are fatal. This is because there are little data on safety on newer drugs such as ocrelizumab. Alemtuzumab was in fact withdrawn from the market in Italy following serious adverse reactions with Cytomegalovirus reactivation. The decrease in lymphocytes in the blood is the cause of major complications after entry of the virus through the renin-angiotensin system [Figure 1]. Fingolimod leads to serious adverse rations, and the most frequent are infections. Teriflunomide and dimethyl fumarate lead to a slight reduction in white cell counts with growth risk of infection. Based on the present literature, postmarketing pharmacovigilance data and Summary of Product Characteristics, it is clear that there is an increased risk of infection associated with drugs for MS. The marked reduction in IgG and IgA leads to an increased risk of causing infection, and hence, the drugs for MS that cause a high reduction in IgG lead to a marked risk of infection for the patient. Drugs such as Ocrelizumab Cladribina should definitely be avoided because of their marked lymphocytopenia.[3],[4],[5]
Figure 1: Increased risk is closely related to increased lymphopenia

Click here to view


We have thoroughly reviewed and compared all the positions of scientific societies and regulatory agencies in different countries, trying to understand the individual position on whether to discontinue current treatment with MS drugs. In general, in Italy, there are currently no indications for discontinuing the various drugs used in MS and exposing the patient to the risk of reactivation of the disease. It is therefore recommended to continue treatment with the current therapy, particularly with all first-line treatments (interferons, glatiramer acetate, teriflunomide, dimethylfumarate). For named depletive therapies such as ocrelizumab or rituximab it should be considered on a case-by-case basis whether to postpone the start of treatment if the patient is already on therapy and therefore already immunosuppressed the cycle should be completed by recommending more precautions. Finally, in case of confirmed Sars-CoV-2 infection, suspend any line I and II therapy until the clinical picture is resolved or a specialist reassessment is made. Considering individual drugs and countries, the recommendations for natalizumab in Italy are that treatment can be started in patients or continued in patients who were already taking it, suspended in case of confirmed Sars- CoV-2 infection. In the United Kingdom, it is recommended to continue treatment. In Germany, natalizumab is not mentioned, in Canada, it is recommended to prescribe it normally also in case of Sars- CoV-2. For dimethylfumarate in Italy, doctors are recommended to carefully consider the benefits and risks for patients who need to isolate themselves as much as possible to avoid infection. In the UK treatment with dimethylfumarate is considered safe, in Germany, it is considered safe and the risk of infection should not increase and it is recommended not to interrupt the monitoring of leukocyte count. For NFI in Italy, it is recommended to continue treatment even in case of Sars- CoV-2 infection at the discretion of the treating physician, the continuation of NFI for any antiviral action data in the literature could be of added value. In the UK, it is considered safe to start or continue treatment with NFI and to stop treatment in case of Sars-cov-2 infection. In Germany, it is recommended that NFI can continue to be prescribed normally, in the USA and Canada it is recommended not to stop treatment. In Italy it is recommended to postpone the start of depletive therapy with ocrelizumab, alemtuzumab, rituximab and cladribine. In patients treated with anti-CD20, it is suggested to delay the infusion even beyond 6 months, if the B-lymphocytes are zero at the expected time of reinfusion. In the UK, patients already on ocrelizumab treatment are recommended to postpone treatment until the epidemic is resolved and for alemtuzumab and cladribine which are considered less safe than natalizumab and ocrelizumab it is recommended not to start them. In Germany, it is recommended to consider postponing the start of depletive therapy in older patients or those with concomitant cardiovascular lung disease and to stop in case of infection. Finally, for fingolimod teryflunomide and glatiramer is recommended to continue treatment in case of Sars-Cov-2 infection and to stop all treatments. In the United Kingdom, it is considered safe to start or continue treatment with glatiramer and teriflunomide and it is recommended to stop treatment in case of SARS-Cov-2 infection. Fingolimod probably moderately increases the risk of infection. In Germany, Glatiramer and teriflunomide may continue to be prescribed normally. Fingolimod may increase the risk of respiratory complications. In the United States and Canada, they may be prescribed and if you have an infection contact doctor.

In recent years, drugs with increased immunosuppressive power have been developed for the treatment of MS. However, these drugs are not free from serious adverse reactions. In this period of global SARS- CoV-2 pandemic, the use of these new immunomodulatory drugs has raised even more the issue of safety and increased potential risks of infection. The question is: Can therapy with these drugs continue during this pandemic period? Or should it be discontinued? The positions of scientific societies and regulatory bodies in different countries, as described above, and given the complication of MS treatment, it would be appropriate to identify the decision-making process on the individual condition of the patient.

Acknowledgment

The authors have nothing to say about ethical standards, ethical approval and funding. This manuscript is not a clinical trial and does not violate ethical rules. No funding has been received for its preparation.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Vitiello A, Ferrara F, Pelliccia C, Granata G, La Porta R. Cytokine storm and colchicine potential role in fighting SARS-CoV-2 pneumonia. Ital J Med 2020;14:88-94.  Back to cited text no. 1
    
2.
Ferrara F, Granata G, Pelliccia C, La Porta R, Vitiello A. The added value of pirfenidone to fight inflammation and fibrotic state induced by SARS-CoV-2 : Anti-inflammatory and anti-fibrotic therapy could solve the lung complications of the infection? Eur J Clin Pharmacol. 2020 Nov;76(11):1615-1618. doi: 10.1007/s00228-020-02947-4.  Back to cited text no. 2
    
3.
Wijnands JM, Kingwell E, Zhu F, Zhao Y, Fisk JD, Evans C, et al. Infection-related health care utilization among people with and without multiple sclerosis. Mult Scler 2017;23:1506-16.  Back to cited text no. 3
    
4.
Vitiello A, La Porta R, Ferrara F. Sacubitril, valsartan and SARS-CoV-2. BMJ Evid Based Med. 2020 Jul 27:bmjebm-2020-111497. doi: 10.1136/bmjebm-2020-111497.  Back to cited text no. 4
    
5.
Vitiello A, Ferrara F. Correlation between renin-angiotensin system and Severe Acute Respiratory Syndrome Coronavirus 2 infection: What do we know? Eur J Pharmacol. 2020 Sep 15;883:173373. doi: 10.1016/j.ejphar.2020.173373.  Back to cited text no. 5
    


    Figures

  [Figure 1]



 

Top
Print this article  Email this article
 

    

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow