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Year : 2020  |  Volume : 52  |  Issue : 3  |  Page : 210-212

A rare case of cephalexin-induced acute interstitial nephritis with hypokalemic periodic paralysis

1 Department of Nephrology and Renal Transplant Medicine, VMMC and Safdarjung Hospital, New Delhi, India
2 Department of Anesthesiology, VMMC and Safdarjung Hospital, New Delhi, India

Correspondence Address:
Dr. Kavish Sharma
Department of Nephrology and Renal Transplant Medicine, VMMC and Safdarjung Hospital, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijp.IJP_532_19

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Drug-induced acute interstitial nephritis (AIN) is often encountered in clinical practice. Cephalexin is a first-generation cephalosporin with antimicrobial sensitivity ranging from Gram-positive to Gram-negative organisms. Cephalexin-induced AIN presenting with hypokalemic periodic paralysis (HPP) has been rarely reported. A 34-year-old female with recent history of oral cephalexin intake presented with acute onset paraplegia with deranged renal parameters and hypokalemia. She was treated conservatively with mechanical ventilator support. HPP could be a rare clinical presentation for cephalexin-induced AIN.


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