| DRUG WATCH |
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| Year : 2018 | Volume
: 50
| Issue : 6 | Page : 354-357 |
Digital gangrene induced by inadvertent intra-arterial cocktail injection of anesthetic agents such as pentazocine, promethazine, and atropine: A serious adverse drug experience
Sonia Shinde Mahajan1, Vishal R Tandon1, Rajat Sarin1, Roshi1, Akhil Kumar Gupta2, Arvind Kohli2
1 Department of Pharmacology and Therapeutics, Government Medical College, Jammu, Jammu and Kashmir, India
2 Department of CTVS, Superspecialty Hospital, GMC, Jammu, Jammu and Kashmir, India
Correspondence Address:
Dr. Vishal R Tandon
Department of Pharmacology and Therapeutics, Government Medical College, Jammu, Jammu and Kashmir
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijp.IJP_131_18
Gangrenous changes in skin due to accidental intra-arterial injection of promethazine and pentazocine have been reported. Accidental intra-arterial injection is most commonly encountered in the antecubital fossa. However, recent reports in the radial and ulnar arteries have also been encountered. We hereby report a serious, preventable adverse drug experience in the form of digital gangrene induced by inadvertent intra-arterial cocktail injection of anesthetic agents such as pentazocine, promethazine, and atropine, which seems to be in the radial artery as the lateral three digits and dorsum of the hand are affected.
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