| RESEARCH ARTICLE |
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| Year : 2018 | Volume
: 50
| Issue : 5 | Page : 227-235 |
Effect of Vaccinium macrocarpon on MK-801-induced psychosis in mice
Disha Shukla1, Rajesh A Maheshwari1, Kirti Patel2, R Balaraman1, Ashim Kumar Sen1
1 Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India
2 Faculty of Pharmacy, The M. S. University of Baroda, Vadodara, Gujarat, India
Correspondence Address:
Ms. Disha Shukla
Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara - 391 760, Gujarat
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijp.IJP_74_17
OBJECTIVES: This study was aimed to investigate the effect of aqueous cranberry extract (ACE) on MK-801-induced psychosis in mice.
MATERIALS AND METHODS: MK-801-treated mice were administered ACE (1 and 2 g/kg, p.o.) for 14 days. Various behavioral parameters and neurochemical estimations such as dopamine (DA), 5-hydroxytryptamine (5-HT), norepinephrine (NE), gamma-aminobutyric acid (GABA), glutamate, and glycine as well as markers of oxidative stress such as nitrite levels were measured.
RESULTS: Psychosis-induced mice showed a significant elevation of immobility time in forced swim test, locomotor activity, and reduction in time of permanency in rota-rod test, escape latency time in Cook's pole test while treatment with ACE showed a significant alteration in above-mentioned behavioral parameters in MK-801-induced psychosis. Moreover, MK-801-induced psychosis in the mice showed a significant increase in DA, 5-HT, and NA levels and decrease in GABA, glutamate, and glycine levels in the brain. In contrast, treatment with ACE at both doses remarkably altered the neurochemical parameters. In addition, ACE-treated mice showed a substantial reduction in acetylcholinesterase, D-amino acid oxidase enzyme activity, and nitrite levels which were elevated by the administration of MK-801.
CONCLUSIONS: Treatment with ACE once for 14 days (1 and 2 g/kg) significantly ameliorated the behavioral symptoms in experimentally induced psychosis by virtue of neuromodulation and decreased oxidative stress.
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