| DRUG WATCH |
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| Year : 2017 | Volume
: 49
| Issue : 6 | Page : 470-471 |
Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis
Piotr Brzezinski1, Sandra Jerkovic Gulin2, Dario Gulin3, Anca Chiriac4
1 Department of Dermatology, 6th Military Support Unit, Ustka, Poland
2 Department of Dermatology and Venereology, General Hospital Sibenik, Sibenik, Croatia
3 Department of Cardiovascular Diseases, University Hospital “Sveti Duh,” Zagreb, Croatia
4 Department of Dermatology, Nicolina Medical Centre, Apollonia University, “P.Poni” Research Institute of Macromolecular Chemistry, Lasi, Romania
Correspondence Address:
Sandra Jerkovic Gulin
Department of Dermatology and Venereology, General Hospital Sibenik, Croatia, Stjepana Radica 83, 22000, Sibenik
Croatia
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijp.IJP_838_16
We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment.
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