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Year : 2017  |  Volume : 49  |  Issue : 6  |  Page : 470-471

Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis

1 Department of Dermatology, 6th Military Support Unit, Ustka, Poland
2 Department of Dermatology and Venereology, General Hospital Sibenik, Sibenik, Croatia
3 Department of Cardiovascular Diseases, University Hospital “Sveti Duh,” Zagreb, Croatia
4 Department of Dermatology, Nicolina Medical Centre, Apollonia University, “P.Poni” Research Institute of Macromolecular Chemistry, Lasi, Romania

Correspondence Address:
Sandra Jerkovic Gulin
Department of Dermatology and Venereology, General Hospital Sibenik, Croatia, Stjepana Radica 83, 22000, Sibenik
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijp.IJP_838_16

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We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment.


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