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Year : 2017  |  Volume : 49  |  Issue : 4  |  Page : 312-316

Hemorheological effects of amlodipine in spontaneously hypertensive rats

Department of Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia

Correspondence Address:
Mark B Plotnikov
634028, Russian Federation, 3 Av. Lenin, Tomsk
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijp.IJP_176_16

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OBJECTIVES: The effect of course administration of amlodipine on whole blood viscosity and on macro- and microrheological parameters was evaluated. MATERIALS AND METHODS: SHRs were treated intragastrically with amlodipine at a dose of 10 mg/kg for 6 weeks. After finishing the course, hemodynamic and hemorheological parameters were measured. RESULTS: The antihypertensive treatment with amlodipine resulted in a significant decrease in mean blood pressure by 29% and left ventricular to body weight mass index by 7%. Nevertheless, BV tended to increase. The administration of amlodipine had no effect on PV, plasma fibrinogen concentration, RBC aggregation, and RBC deformability, but hematocrit was higher (by 6%) than it was in control group. CONCLUSIONS: These results demonstrate that amlodipine has no positive hemorheological improvements when administered to SHRs.


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