IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1393 
Small font sizeDefault font sizeIncrease font size
Navigate Here
Resource Links
 »  Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »  Article in PDF (874 KB)
 »  Citation Manager
 »  Access Statistics
 »  Reader Comments
 »  Email Alert *
 »  Add to My List *
* Registration required (free)

In This Article
 »  Abstract
 » Methodology
 » Discussion
 »  Conclusion and R...
 »  References
 »  Article Tables

 Article Access Statistics
    PDF Downloaded104    
    Comments [Add]    

Recommend this journal


 Table of Contents    
Year : 2017  |  Volume : 49  |  Issue : 1  |  Page : 89-92

Pricing and components analysis of some key essential pediatric medicine in Odisha state

1 Department of Pharmacology, VIMSAR, Burla, Sambalpur, Odisha, India
2 Department of Pharmacology, SCB Medical College, Cuttack, Odisha, India

Date of Submission01-Aug-2016
Date of Acceptance08-Dec-2016
Date of Web Publication27-Feb-2017

Correspondence Address:
Satyajit Samal
Department of Pharmacology, VIMSAR, Burla, Sambalpur, Odisha
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.201021

Rights and Permissions

 » Abstract 

Objective: Study highlighting prices, i.e., the patients actually pay at ground level is important for interventions such as alternate procurement schemes or to expedite regulatory assessment of essential medicines for children. The present study was undertaken to study pricing and component analysis of few key essential medicines in Odisha state.
Methodology: Six child-specific medicines of different formulations were selected based on use in different disease condition and having widest pricing variation. Data were collected, entered, and analyzed in the price components data collection form of the World Health Organization-Health Action International (WHO-HAI) 2007 Workbook version 5 - Part II provided as part of the WHO/HAI methodology. The analysis includes the cumulative percent markup, total cumulative percent markup, and percent contribution of individual components to the final medicine price in both public and private sector of Odisha state.
Results: Add-on costs such as taxes, wholesale, and retail markups contribute substantially to the final price of medicines in private sector, particularly for branded-generic products. The largest contributor to add-on costs is at the level of retailer shop.
Conclusion: Policy should be framed to achieve a greater transparency and uniformity of the pricing of medicines at different health sectors of Odisha.

Keywords: Essential medicines, markup, pricing, private sector

How to cite this article:
Samal S, Swain TR. Pricing and components analysis of some key essential pediatric medicine in Odisha state. Indian J Pharmacol 2017;49:89-92

How to cite this URL:
Samal S, Swain TR. Pricing and components analysis of some key essential pediatric medicine in Odisha state. Indian J Pharmacol [serial online] 2017 [cited 2023 Nov 28];49:89-92. Available from: https://www.ijp-online.com/text.asp?2017/49/1/89/201021

More than half the population does not have access to essential life-saving medicines in most of the impoverished parts of Africa and of Asia. Rapidly rising costs of health care and high medicine prices are a growing concern in developing countries where patients often have to pay the full price of medicines.[1] It is now considered as the right of every human being to have access to essential drugs.[2] Odisha is one of the least urbanized states in India, with an infant mortality rate second highest in the country.[3] Control of pharmaceutical pricing in India comes under the Ministry of Chemical and Fertilizer which has established an independent body of experts National Pharmaceutical Pricing Authority (NPPA) to monitor prices of medicines. Price-controlled drugs are divided into two categories; the first category scheduled medicines include drugs considered as essential and are subject to more stringent control rules.[4] Rest of the medicines called nonscheduled medicines, manufacturer sets the price and registers the price with NPPA.[5] The previous studies involving pricing and availability of key essential pediatric medicines has revealed that there is a wide variation in prices in private sector.[6] The present study was planned to explore the prices the patients actually pay and the exact level at which the child-specific medicines gain price so that a strategy for proper intervention can be devised at by the Government or regulators.

 » Methodology Top

This World Health Organization (WHO) supported survey program regarding the prices of medicines in Orissa was conducted between January 15, 2014, and February 15, 2015 using the standardized WHO/Health Action International (HAI) methodology (WHO/HAI 2008) developed by the WHO and HAI accessible on the HAI website (http://www.haiweb.org/medicineprices).[7] The survey included two parts: a pharmaceutical policy investigation at the central level and research into actual price components along the medicine distribution chain.[7] At the central level, information was collected on government taxation policies and regulations that affect the prices of medicines from manufacture to consumer. In actual price component study, medicines were traced backward through the supply chain, from dispensing point to importer or local manufacturer, and different charges and markups were identified.[7] The six medicines shown in [Table 1] were selected based on use in common disease conditions, constituting different formulations, having wide pricing variation, and finally taking into consideration their availability in private, public, and nongovernmental organization (NGO) sectors. Each medicine was divided into different product basing on (a) sector (private/public/other), (b) import or locally produced, and (c) product type (originator or generic).
Table 1: List of medicines tracked through the supply chain

Click here to view

In case of public sector, for each product, data were collected from State Drug Monitoring Unit, Bhubaneswar, procurement division by reviewing purchase order of different medicines. In case of private/NGO sector, different products basing on highest priced or lowest priced, originator, or generic were selected from data of the previous studies involving pricing and availability.[6] For each product, one retail pharmacy was interviewed, and actual invoice was reviewed. These products were traced backward through the supply chain, from dispensing point to wholesaler, local manufacturer/importer, and different charges and markups were identified.

Data Collection

Tracking of medicine pricing survey was conducted in two regions: Cuttack (urban) and Balasore (rural) districts. For all the six medicines, target products consisting of the highest priced and lowest priced product were selected. Data were collected for dispensed price, procurement price of retail and wholesale, landed price, and manufacturer selling price (MSP). Data collection started at the end of the supply chain (retail pharmacy and public sector outlet) and then worked backward in stepwise manner. For example, in case of private retail pharmacies, data collected on procurement price, dispensing price, any markups, taxes, dispensing fees, and the wholesalers from which medicine was procured. Next, the wholesalers were visited and data collected on procurement price, distribution costs, wholesale markups, and any taxes.[8] Data collection in this manner for the same medicine products, and for the same pack size at different stages of the supply chain, was started from retail pharmacies and ended with the manufacturer.

Data Entry and Analysis

Data entry and analysis were done in preprogrammed WHO-HAI 2007 Workbook Version 5 - Part II provided as part of the WHO/HAI methodology. All data were collected in the price components data collection form were entered in the Medicines Price Workbook, and were analyzed according to five common stages of the supply chain:

  • Stage 1:MSP
  • Stage 2: Landed price (for imported medicines)/Super stockist selling price
  • Stage 3: Wholesale selling price (private) or central medical stores price (public)
  • Stage 4: Retail price (private) or dispensary price (public)
  • Stage 5: Dispensed price or final price.

Data analysis included the cumulative percent markup at the end of each stage, the total cumulative percent markup and the percent contribution of individual components to the final medicine price.[8]

Observation and Result

The present survey on price components of medicines was done in Odisha state of India following WHO/HAI methodology. Six different medicines were selected and classified into different product types basing on sector to which it belongs and product type. Prices of these are surveyed in different stages in public and private sector.

Public Sector

In the public sector, the cumulative percentage markups were approximately 10% with only small variation observed across individual medicines [Table 2]. The principal contributors to this markup were central sales tax with entry tax (3%) and super-stockist markup (2%) both applied in Stage 2, and a value-added tax (VAT) of 4% applied to Stage 5.
Table 2: Cumulative percentage markups for generic medicines in the public sector

Click here to view

Private Sector

In private sector, the cumulative markup on branded products was approximately 53% [Table 3]. Stage 2 charges comprised central sale tax (2%) and entry tax (1%), as well as the super-stockist markup (generally 3%). Wholesale and retail markups are represented in Stages 3 and 4, respectively while the 4% VAT applied to all medicines is accounted for Stage 5. However, in case of branded generics, a much larger cumulative percent markup (218% and 325%) was seen in paracetamol suspension and oral rehydration solution (ORS) powder. [Graph 1] represents the difference between markup structures in public and private sectors for generic, branded, and branded generic product of paracetamol suspension. In the public sector, the MSP contributes 90% to the final patient price and the add-on costs of the supply chain only contribute 10%. Conversely, in private sector, MSP only contributes 30%–65%, and add-on costs contribute 35%–70%. This is generally due to the higher retail markup applied for branded generics in private sector (in this case contributing 61% to the final price). The difference between markup structures of branded and branded-generic products of paracetamol suspension are also depicted in Graph 1 which shows the percentage contribution of price components to the final price. For branded products, the MSP is the largest contributor to final price (around 65%). However, for the branded generic such as paracetamol suspension and ORS powder, the retail markup is the largest contributor (61% and 67%), with the MSP only accounting for 31% and 23%, respectively, of the final price.
Table 3: Cumulative percentage markup of products in private sector

Click here to view

 » Discussion Top

In the public sector, add-on costs represent 10% of the final patient price for generics medicines, with largest contributor at Stage - 2 (central sales tax + entry tax, and super-stockist markup). In private sector, add-on costs, such as taxes, wholesale, and retail markups, contribute substantially to the final price of medicines, contributing approximately 35% of the final patient price for branded medicines and 70% for unbranded generics. The largest contributor to add-on cost is retailer markup which also includes the operating cost of transportation, storage, and dispensing medicines. The high variability of price between private sector outlets is likely the result of low market competition and absence of proper price regulation.[6] Our findings also match with price components survey in Mongolia, which also revealed that cumulative percent markups for individual medicines ranged from 37.5% to 115.53% in private sector with major contributions to final price from retail markup (30.44% of final price) and wholesale markup (15.7% of final price).[8]

The study results may be limited by the fact that most of the data collected are subjective and may be influenced by market fluctuations and delivery schedules. The operating cost of transportation, storing, and dispensing of medicines could not be separated from the markups at wholesaler and retailer stage. Finally, the methodology does not include bonus pack given by manufactures, informal sectors such as markets and general stores, as the quality of the medicines found in such sectors cannot be assured. Thus, our study highlights variation of prices of essential child medicines across different sectors and the cause behind the price variation. Proper policy can be framed and implemented to control medicine price or to go for alternate procurement schemes at least with essential medicines for children.

 » Conclusion and Recommendation Top

This study has helped to provide broad insight into price and affordability of key medicines for the treatment of common conditions. A set of policies needs to be implemented to make medicines accessible to poor patients. The policy should be framed to achieve greater transparency and uniformity in the pricing of medicines. Promotion and acceptance of generic medicine among the health professionals should be done by providing adequate training for doctors to improve prescribing practices around cost-effective generics. Regulatory authorities should think of importing more child-specific formulations for the state. The cost of medicines in private sector should be lowered by specific policy change. Although further investigation is required to obtain a more in-depth understanding of the causes and consequences of medicine pricing, the results of this survey provide broad directions for future research and action. It is, therefore, recommended that the Government of Odisha should procure children's medicine on a priority basis looking at the very high childhood morbidity and mortality and excellent purchasing efficiency.


We are thankful to Prof. B. Gitanjali, Prof. A. Kotwani, K. Weerasuriya, Drugs Controller, Odisha, and Director of Health Services, Odisha, for facilitating this project work.

Financial Support and Sponsorship

This study was supported by the WHO SEARO, New Delhi.

Conflicts of Interest

There are no conflicts of interest.

 » References Top

Medicine Prices, Availability, Affordability and Price Components. Available from: http://www.apps.who.int/medicinedocs/documents/s16180e/s16180e.pdf. [Last accessed on 2014 Jun 24].  Back to cited text no. 1
World Health Organization. 'Essential Medicines: Definition'. Available from: http://www.who.int/medicines/services/essmedicines_def/[Last accessed on 2016 Jun 24].  Back to cited text no. 2
UNICEF India – Orissa. Available from: http://www.unicef.org/India/overview_4346.htm. [Last accessed on 2013 Feb 06].  Back to cited text no. 3
Kotwani A. Medicine Prices in the State of Rajasthan, India; 2004. Available from: http://www.haiweb.org/medicineprices/surveys/200306IN/survey_report.pdf. [Last accessed on 2012 Jun 22].  Back to cited text no. 4
Government of India, National Pharmaceutical Pricing Authority Homepage, Drugs (Price Control) Order; 2013. Available from: http://www.nppaindia.nic.in/index1.html. [Last accessed on 2014 Feb 06].  Back to cited text no. 5
Swain TR, Rath B, Dehury S, Tarai A, Das P, Samal R, et al. Pricing and availability of some essential child specific medicines in Odisha. Indian J Pharmacol 2015;47:496-1.  Back to cited text no. 6
[PUBMED]  Medknow Journal  
WHO/HAI Methodology (WHO/HAI 2008) Developed by the World Health Organization (WHO) and Health Action International (HAI). Available from: http://www.who.int/medicines/areas/access/OMS_Medicine_prices.pdf. [Last accessed on 2012 Jun 22].  Back to cited text no. 7
Medicine Prices, Availability, Affordability and Price Components in Mongolia; 2013. Available from: http://www.haiweb.org/wp-content/uploads/2015/07/Mongolia-Report-Pricing-Surveys.pdf. [Last accessed on 2016 Jun 24].  Back to cited text no. 8


  [Table 1], [Table 2], [Table 3]


Print this article  Email this article


Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow