| DRUG WATCH |
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| Year : 2016 | Volume
: 48
| Issue : 3 | Page : 321-323 |
Amphotericin B liposome-induced acrocyanosis and elevated serum creatinine
Xiangcai Zhang1, Jie Jin1, Chuang Cai2, Ren Zheng1, Yu Wang1, Yingying Xu1
1 Department of Pharmacy, Hangzhou Red Cross Hospital, Hangzhou 310003, China
2 Department of Respiration, Hangzhou Red Cross Hospital, Hangzhou 310003, China
Correspondence Address:
Yingying Xu
Department of Pharmacy, Hangzhou Red Cross Hospital, Hangzhou 310003
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.182889
A 77-year-old male patient developed acrocyanosis and pain after treatment with amphotericin B liposome 150 mg daily intravenously for disseminated histoplasmosis, and subsequently developed elevated serum creatinine. Amphotericin B liposome was discontinued, and anisodamine was used intravenously to treat acrocyanosis and pain induced by amphotericin B liposome for 9 days and patient was cured. Naranjo adverse drug reaction probability scale score was 5, the World Health Organization-Uppsala Monitoring Centre criteria: Probable, indicating a probable adverse reaction to amphotericin B liposome.
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