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Year : 2016  |  Volume : 48  |  Issue : 3  |  Page : 312-315

Anabolic therapy with Equisetum arvense along with bone mineralising nutrients in ovariectomized rat model of osteoporosis

University Department of Biochemistry, RTM Nagpur University, Nagpur, Maharashtra, India

Correspondence Address:
Dr. Swati D Kotwal
University Department of Biochemistry, RTM Nagpur University, Nagpur, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.182880

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Objective: Equisetum arvense has been used to treat bone diseases. The traditional supplementation of calcium and Vitamin D for osteoporosis patients is insufficient considering the rise in patients every year. We have observed that extending the calcium and Vitamin D supplement with L-lysine, L-proline, L-arginine, and L-ascorbic acid (N) positively affects bone mineralization in ovariectomized rat. Here, we report a further extension of the above supplement with E. arvense. Materials and Methods: The changes in serum biomarkers, bone mineral content, and femur bone histology were studied and compared to the standard drug for osteoporosis, namely raloxifene (RAL). Results: We report a significant change in formation and resorption markers of bone as well as in cortical bone thickness and trabecular width in N and N + EA groups. The treatment N + EA also restored lipid profile near to normal level compared to ovariectomized group. Conclusions: Treatment N + EA was found to be as effective as RAL in reversing the osteoporotic changes.


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