| RESEARCH ARTICLE |
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| Year : 2016 | Volume
: 48
| Issue : 3 | Page : 286-291 |
The antidepressant- and anxiolytic-like activities of new xanthone derivative with piperazine moiety in behavioral tests in mice
Karolina Pytka1, Elzbieta Zmudzka1, Klaudia Lustyk1, Anna Rapacz1, Adrian Olczyk2, Adam Galuszka2, Anna Waszkielewicz3, Henryk Marona3, Jacek Sapa1, Filipek Barbara1
1 Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Krakow, 44-101 Gliwice, Poland
2 Institute of Automatic Control, Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, 44-101 Gliwice, Poland
3 Department of Bioorganic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Krakow, 44-101 Gliwice, Poland
Correspondence Address:
Dr. Karolina Pytka
Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Krakow, 44-101 Gliwice
Poland
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.182872
Objectives: Xanthones are flavonoids with numerous activities, including antioxidant, antidepressant., or anxiolytic-like. Therefore, the aim of our study was to determine antidepressant- and anxiolytic-like properties of four xanthone derivatives (3-chloro-5-[(4-methylpiperazin-1-yl)methyl]-9H-xanthen-9-one dihydrochloride [HBK-5], 6-methoxy-2-[(4-methylpiperazin-1-yl) methyl]-9H-xanthen-9-one dihydrochloride, 2-[(4-benzylpiperazin-1-yl) methyl]-6-methoxy-9H-xanthen-9-one dihydrochloride, 2-{[4-(2-methoxyphenyl) piperazin-1-yl] methyl}-9H-xanthen-9-one hydrochloride), as well as the influence on cognitive and motor function of active compounds, using animal models.
Materials and Methods: To determine the antidepressant-like activity, we used forced swim test (FST) and tail suspension test (TST) in mice. We evaluated anxiolytic-like properties in the four-plate test in mice. We studied the influence on cognitive and motor function in passive avoidance step.through and chimney tests, respectively.
Results: The antidepressant-like activity (in both FST and TST) showed only HBK-5. Moreover, the compound was also active in the four-plate test, which suggests that it possessed anxiolytic-like properties. HBK-5 did not cause any cognitive and motor deficits in mice at antidepressant- and anxiolytic-like doses.
Conclusions: HBK-5 may have potential in the treatment of depression or anxiety disorders, but this issue needs further studies.
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