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Year : 2015  |  Volume : 47  |  Issue : 5  |  Page : 540-545

Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril

1 Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State, Nigeria
2 Department of Medicine, Enugu State University of Science and Technology, Enugu, Enugu State, Nigeria
3 Department of Physiology, School of Basic Medical Sciences, University of Benin, Benin City, Edo State, Nigeria
4 Department of Ophthalmology, University of Nigeria Teaching Hospital, Enugu, Enugu State, Nigeria

Correspondence Address:
Dr. Daniel Chukwu Nwachukwu
Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State
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Source of Support: Nil., Conflict of Interest: There are no conflicts of interest.

DOI: 10.4103/0253-7613.165194

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Objectives: The present study investigated the effects of aqueous extract of Hibiscus sabdariffa (HS) on the three basic components of renin-angiotensin-aldosterone system: Plasma renin, serum angiotensin-converting enzyme (ACE), and plasma aldosterone (PA) in mild to moderate essential hypertensive Nigerians and compared with that of lisinopril, an ACE inhibitor. Materials and Methods: A double-blind controlled randomized clinical study was used. Seventy-eight newly diagnosed but untreated mild to moderate hypertensive subjects attending Medical Outpatients Clinic of Enugu State University Teaching Hospital, Enugu were recruited for the study. Those in Group A received placebo (150 mg/kg/day), Group B were given lisinopril (10 mg once daily) while those in Group C received aqueous extract of HS (150 mg/kg/day). After 4 weeks of treatment, the levels of plasma renin, serum ACE, and PA were determined. Results: HS and lisinopril significantly (P < 0.001) reduced PA compared to placebo by 32.06% and 30.01%, respectively. Their effects on serum ACE and plasma renin activity (PRA) were not significant compared to placebo; they reduced ACE by 6.63% and 5.67% but increased plasma PRA by 2.77% and 5.36%, respectively. Conclusion: HS reduced serum ACE and PA in mild to moderate hypertensive Nigerians with equal efficacy as lisinopril. These actions are possibly due to the presence of anthocyanins in the extract.


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