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 Table of Contents    
Year : 2015  |  Volume : 47  |  Issue : 4  |  Page : 425-429

In-vitro α-amylase and α-glucosidase inhibitory activity of Adiantum caudatum Linn. and Celosia argentea Linn. extracts and fractions

Department of Pharmacognosy, KLES College of Pharmacy, Belagavi, Karnataka, India

Date of Submission08-Apr-2015
Date of Decision11-Jun-2015
Date of Acceptance26-Jun-2015
Date of Web Publication21-Jul-2015

Correspondence Address:
Dr. Kirankumar Hullatti
Department of Pharmacognosy, KLES College of Pharmacy, Belagavi, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.161270

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 » Abstract 

Objective: The objective of the present study was to provide an in-vitro evidence for the potential inhibitory activity of extracts and fractions of Adiantum caudatum Linn. and Celosia argentea Linn. on α-amylase and α-glucosidase enzymes .
and Methods: The plant extracts were prepared, first with cold maceration (70% v/v ethanol) and then by Soxhlation techniques (95% v/v ethanol). Subsequently, the combined extracts were subjected for fractionation. Different concentrations (0.1, 0.2, 0.3, 0.4, and 0.5 mg/ml) of extract and fractions were subjected to α-amylase and α-glucosidase inhibitory assay. The absorbance was measured at 540 and 405 nm using multiplate reader and the percentage of α- amylase and α- glucosidase inhibitory activity and IC 50 values of extract and fractions were calculated.
Results: Fraction 2 of A. caudatum and fraction 4 of C. argentea has shown highest α-amylase and α-glucosidase inhibitory potential with IC 50 values of 0.241, 0.211 and 0.294, 0.249 mg/ml, respectively, which was comparable with acarbose (0.125 and 0.93 mg/ml). Whereas, extracts and remaining fractions of both the plants have shown lesser activity.
Conclusion: The results of the present study indicate that, fraction 2 of A. caudatum, rich in triterpenoids and phenolics and fraction 4 of C. argentea, rich in flavonoids, are effective α- amylase and α- glucosidase inhibitors, which may be helpful to reduce the postprandial glucose levels. Hence, further studies may throw light on the antidiabetic potential of A. caudatum and C. argentea, especially in the management of type 2 diabetes.

Keywords: α- amylase, α-glucosidase, Mayurasikha, type 2 diabetes

How to cite this article:
Telagari M, Hullatti K. In-vitro α-amylase and α-glucosidase inhibitory activity of Adiantum caudatum Linn. and Celosia argentea Linn. extracts and fractions. Indian J Pharmacol 2015;47:425-9

How to cite this URL:
Telagari M, Hullatti K. In-vitro α-amylase and α-glucosidase inhibitory activity of Adiantum caudatum Linn. and Celosia argentea Linn. extracts and fractions. Indian J Pharmacol [serial online] 2015 [cited 2023 Sep 25];47:425-9. Available from: https://www.ijp-online.com/text.asp?2015/47/4/425/161270

 » Introduction Top

Diabetes mellitus is a chronic metabolic disorder, characterized by hyperglycemia and carbohydrate, protein, and fat metabolic disturbances. It causes failing of insulin production or insulin action or both. According to an estimation of the International Diabetes Federation, approximately 366 million people are suffering from diabetes and this may double by 2030, in India to be 40.9 million, which is expected to grow to 60.9 million by 2025. [1] Between two types of diabetes, type 2 is more prevalent than type 1, with more than 90% of the total diabetic patients suffering from it. Type 2 diabetes (T2D) is a disease caused by an imbalance between blood sugar absorption and insulin secretion. Postprandial hyperglycemia plays an important role in the development of T2D. [2] Regulating plasma glucose level is vital for delaying or preventing T2D. The ability of a drug or diet to delay the production or absorption of glucose by inhibiting carbohydrate hydrolyzing enzymes such as α-amylase and α-glucosidase is one of the therapeutic approaches for decreasing postprandial hyperglycemia. [3] At present, the use of insulin secretagogues and sensitizers constitute the predominant line of therapy, however, the use of carbohydrate digesting enzyme inhibitors play a vital role in controlling hyperglycemia by reducing the intestinal absorption of glucose. [4] Acarbose is one of the leading inhibitor of carbohydrate metabolic enzymes in the gastrointestinal tract, but it is associated with side effects such as diarrhea and other intestinal disturbances such as bloating, flatulence, cramping, and abdominal pain. [5] World Health Organization (WHO) estimates that about three-quarters of the population mainly in the countries of Africa, Asia, and Latin America, confides on plant based preparations in their traditional medicinal system for primary healthcare (WHO, 2003). This dependence increased the knowledge gathering and exploration of novel and effective plant-derived compounds for commercialization. Predominantly herbal drugs have been widely used globally for diabetic treatment over thousands of years due to their traditional acceptability and lesser side effects. Therefore, screening of α-amylase and α-glucosidase inhibitors in medicinal plants has received much attention.

Ayurveda and other Sanskrit literature describe Mayurasikha as a Sandigdha dravya (controversial drugs). Which having more than one botanical source. [6] Dravyaguna Vijnana by P.V. Sharma named Adiantum caudatum as Mayurasikha and Shaligramanighantubhushanam describes Celosia argentea (syn-celosia cristata) as Mayurasikha. Hence, these two plants were selected for comparative evaluation of α-amylase and α-glucosidase inhibitory activity. [7],[8]

A. caudatum Linn. (Pteridaceae) is a fern, which is available especially lower slopes of the hills in Punjab, Rajasthan, West Bengal, Tamil Nadu, and Maharashtra. Ayurveda describes that it would be useful treat Prameha (diabetes), Atisara, Pravahika, cough, skin diseases, and fever. [6]

C. argentea Linn. (Amaranthaceae) is annual herb (0.5-1.5 m), a common weed, occurring throughout India. In Indian folk medicine, it was used for diabetes and the seeds were used in the treatment of jaundice, gonorrhea, wounds, and fever. [9]

There are scanty reports available regarding the phytoconstituents responsible for inhibiting the carbohydrate digestive enzymes, which can able to manage diabetes mellitus. Hence, the main objective of present study was to investigate in-vitro, α-amylase, α-glucosidase inhibitory activity of the hydro-alcoholic extract, and fractions of A. caudatum and C. argentea.

 » Materials and Methods Top


α-glucosidase (Saccharomyces cerevisiae), α-amylase (procaine pancreas) and 3, 5, di-nitro salicylic acid (DNS) were purchased from Sigma-Aldrich, Bangalore. P-nitro-phenyl-α-D-glucopyranoside (p-NPG), sodium carbonate (Na 2 CO 3 ), sodium dihydrogen phosphate, di-sodium hydrogen phosphate were purchased from Hi-Media, Mumbai.

Plant Material

caudatum and C. argentea were collected during the month of August 2013 from adjoining areas of Visvesvaraya Technological University, Belagavi, Karnataka. Authentication of the plants was done by Dr. Harsha Hegde, Scientist C (RMRC, Belgaum), and a voucher specimens (RMRC-985, 987) was deposited at RMRC (ICMR), Belagavi. The plant material was washed under running tap water and dried under shade, coarsely powdered (#2000/335), and stored in the neatly labeled airtight container.

Extraction and Fractionation

Dried powdered (500 g) material was first subjected to cold maceration to extract thermolabile constituents if any with 70% v/v ethanol for 24 h. Extract was filtered, and the marc was further subjected for soxhlation (95% v/v ethanol). Filtrates of both maceration and soxhlation were combined and concentrated using a rotary evaporator (IKA RV 10) at 40°C under reduced pressure, which yields total extract of 40 g and 46 g.

Fractionation of A. caudatum extract was carried out as per Cos et al., with minor modifications [Figure 1]. [10] Alcoholic extract was dispersed in 5% w/v citric acid and washed with dichloromethane. Dichloromethane layer was separated and it was concentrated to 1/3 rd volume using rotary evaporator at 40°C under reduced pressure. Concentrated dichloromethane layer was partitioned with 90% v/v methanol and petroleum ether (1:1) to get fraction 1, (F1, 9.65 g) and fraction 2, (F2, 7.15 g). Aqueous layer was concentrated to half and pH adjusted to 9.0 with 10% ammonium hydroxide . Aqueous layer was washed with dichloromethane, which gives fraction 3 and fraction 4 (F3, 0.584, and F4, 16.45 g). Same procedure was used for fractionation of C. argentea extract and percentage yield of the fractions were F1 10.15 g, F2 9.76 g, F3 0.593 g, and F4 18.65 g, respectively.
Figure 1: Scheme for preparation of fractions

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In-vitro Assay

α-amylase inhibitory activity

α-amylase inhibitory activity of extract and fractions was carried out according to the standard method with minor modification. [11] In a 96-well plate, reaction mixture containing 50 μl phosphate buffer (100 mM, pH = 6.8), 10 μl α-amylase (2 U/ml), and 20 μl of varying concentrations of extract and fractions (0.1, 0.2, 0.3, 0.4, and 0.5 mg/ml) was preincubated at 37°C for 20 min. Then, the 20 μl of 1% soluble starch (100 mM phosphate buffer pH 6.8) was added as a substrate and incubated further at 37°C for 30 min; 100 μl of the DNS color reagent was then added and boiled for 10 min. The absorbance of the resulting mixture was measured at 540 nm using Multiplate Reader (Multiska thermo scientific, version 1.00.40). Acarbose at various concentrations (0.1-0.5 mg/ml) was used as a standard. Without test (extract and fractions) substance was set up in parallel as control and each experiment was performed in triplicates. The results were expressed as percentage inhibition, which was calculated using the formula,

Inhibitory activity (%) = (1 − As/Ac) ×100


As is the absorbance in the presence of test substance and

Ac is the absorbance of control.

α-glucosidase inhibitory activity

α-glucosidase inhibitory activity of extract and fractions was carried out according to the standard method with minor modification. [12] In a 96-well plate, reaction mixture containing 50 μl phosphate buffer (100 mM, pH = 6. 8), 10 μl alpha-glucosidase (1 U/ml), and 20 μl of varying concentrations of extract and fractions (0.1, 0.2, 0.3, 0.4, and 0.5 mg/ml) was preincubated at 37°C for 15 min. Then, 20 μl P-NPG (5 mM) was added as a substrate and incubated further at 37°C for 20 min. The reaction was stopped by adding 50 μl Na 2 CO 3 (0.1 M). The absorbance of the released p-nitrophenol was measured at 405 nm using Multiplate Reader. Acarbose at various concentrations (0.1-0.5 mg/ml) was included as a standard. Without test substance was set up in parallel as a control and each experiment was performed in triplicates. The results were expressed as percentage inhibition, which was calculated using the formula,

Inhibitory activity (%) = (1 − As/Ac) ×100


As is the absorbance in the presence of test substance and Ac is the absorbance of control.

Statistical Analysis

All the measurements were done in triplicate and results are expressed in terms of mean ± standard deviation and IC 50 values were calculated using GraphPad Prism 5 version 5.01 (Graph pad software, Inc., La Jolla, CA, USA.) statistical software.

 » Results Top

In the present study, hydro-alcoholic extract and four fractions of A. caudatum and C. argentea were evaluated for their inhibitory effect on α-amylase and α-glucosidase enzymes by in-vitro method. The hydro-alcoholic extract and its fractions 1, 2, 3, and 4 of A. caudatum (at a concentration of 0.5 mg/ml) exhibited 32.42, 46.25, 61.45, 20.12, and 26.04 α-amylase inhibitory activity [Figure 2] and 36.42, 47.25, 63.45, 29.22, and 32.34 α-glucosidase inhibitory activity [Figure 3], respectively. Whereas, C. argentea hydro-alcoholic extract and Fractions 1, 2, 3, and 4 exhibited 22.42, 21.04, 29.04, 30.12, and 59.45 α-amylase inhibitory activity [Figure 4], 37.62, 31.04, 37.24, 29.34, and 61.45 α-glucosidase inhibitory activity, respectively [Figure 5]. Acarbose was used as a standard reference drug, which showed α-amylase inhibitory activity with an IC 50 value of 0.108 mg/ml and α-glucosidase inhibitory activity with an IC 50 value of 0.083 mg/ml. Among all, fraction 2 of A. caudatum and fraction 4 of C. argentea has shown best enzyme inhibitory activity with an IC 50 value 0.241 and 0.211 (α-amylase and α-glucosidase) [Table 1] and 0.294 and 0.249 mg/ml (α-amylase and α-glucosidase) [Table 2] which were comparable with that of acarbose.
Figure 2: α-amylase inhibition of Adiantum caudatum extract and fractions

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Figure 3: α-glucosidase inhibition of Adiantum caudatum extract and fractions

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Figure 4: α-amylase inhibition of Celosia argentea extract and fractions

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Figure 5: α-glucosidase inhibition of Celosia argentea extract and fractions

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Table 1: α-amylase and α-glucosidase inhibitory effects of hydro-alcoholic extract and fractions of Adiantum caudatum, and acarbose

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Table 2: α-amylase and α-glucosidase inhibitory effects of hydro-alcoholic extract and fractions of Celosia argentea, and acarbose

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 » Discussion Top

The use of herbal drugs as complementary approaches in existing medications for the treatment of diabetes and its complications is growing worldwide and many plants in different countries are known to have antidiabetic effects. [13] The ancient Indian literature reports more than 800 plants with antidiabetic properties while ethnopharmacological surveys indicate that more than 1200 plants can be used for hypoglycemic activity. [14] Mainly two carbohydrate hydrolyzing enzymes (α-amylase and α-glucosidase) are responsible for postprandial hyperglycemia. α-amylase begins the process of carbohydrate digestion by hydrolysis of 1, 4-glycosidic linkages of polysaccharides (starch, glycogen) to disaccharides and α-glucosidase catalyzes the disaccharides to monosaccharides, which leads to postprandial hyperglycemia. [15],[16] Hence, inhibitors of α-amylase and α-glucosidase are useful in the control of hyperglycemia as they delay carbohydrate digestion, which consequently reduce the postprandial plasma glucose level. Previously, the antidiabetic activity of A. caudatum and C. argentea has been reported in the literature. The ethanolic extract of A. caudatum whole plant shown antidiabetic activity with 200 mg/kg b.w in streptozotocin-induced diabetic rats. Ethanolic extract of C. argentea roots and seeds with 250 and 500 mg/kg b.w reduced hyperglycemia in streptozotocin and alloxan-induced diabetic rats. [17],[18],[19] There was no information available in the literature about the in-vitro (α-amylase and α-glucosidase inhibitory activity) antidiabetic studies of these two plants. Hence, the present study aimed to evaluate α-amylase and α-glucosidase inhibitory activity of hydro-alcoholic extract and its fractions of A. caudatum and C. argentea. Alkaloids, phenolics, triterpenoids, flavonoids, and steroids were identified in the preliminary phytochemical investigation of A. caudatum. After fractionation of the hydro-alcoholic extract, steroids and lipids were found in fraction 1, phenolics and terpenoids were found in fraction 2. Fraction 3 was shown positive results for alkaloids and fraction 4 shown positive results for flavonoids. Based on the results obtained, fraction 2 was showed highest inhibitory potential than extract and other fractions. Whereas, phytochemical investigation of C. argentea showed positive results for alkaloids, phenolics, triterpenoids, flavonoids, steroids, saponins, and tannins. After fractionation of the hydro-alcoholic extract, steroids, and lipids were found in fraction 1, phenolics, and terpenoids were found in fraction 2. Fraction 3 was shown positive results for alkaloids and fraction 4 shown appreciable levels of flavonoids. Based on the results obtained, fraction 4 of C. argentea shown highest inhibitory potential than extract and other fractions. Many bioactive compounds from different plants have been reported to have hypoglycemic effect, in that mostly phenolics and triterpenoids such as oleanane, ursane, lupane, and flavonoids have a positive correlation as antidiabetic agents. [20],[21],[22] The presence of triterpenoids and phenolics in fraction 2 might have attributed to the highest enzyme inhibition activity compared to other fractions in A. caudatum. [23] Hence, the triterpenoids of this plant may be responsible for enzyme inhibitory activity. Apart from that polyphenolic compounds were found in fraction 2, may interact or inhibit specific positions in enzymes thereby reducing the potency of α-amylase and α-glucosidase. [24] The presence of flavonoid compounds in fraction 4 of C. argentea may act against diabetes mellitus either through their capacity to avoid glucose absorption or to improve glucose tolerance by competitive inhibition of sodium-dependent glucose transporter-1. [25] Another possible mechanism followed by flavonoid compounds (luteolin, kaempferol, chrysin, and galangin) to control blood glucose levels is the inhibition of α-amylase and α-glucosidase activity in the intestine. [26] Due to above reasons, fraction 2 of A. caudatum and fraction 4 of C. argentea showed comparable results with that of acarbose. With the help of results in correlation with previous reports it can be hypothesized that the significant enzyme inhibitory activity of fraction 2 and fraction 4 may interfere or delay the absorption of dietary carbohydrates as well as disaccharides in the small intestine, leading to the suppression of meal-induced increase of plasma glucose. Hence, it may useful in the management of T2D. Based on the lead fractions obtained from in-vitro studies, we are going to plan an in-vivo study for further confirmation of the obtained results.

Limitations of the Study

Active compounds isolation from the fractions and its structural elucidation by nuclear magnetic resonance spectroscopy may helpful to develop newer antidiabetic agents. Here our target was an in-vitro evaluation of α-amylase and α-glucosidase inhibitory activity of the hydro-alcoholic extract, and fractions of A. caudatum and C. argentea.

 » Conclusion Top

The results of the present study prove that the fraction 2 of the A. caudatum and fraction 4 of the C. argentea are effective α-amylase and α-glucosidase inhibitors, which may helpful to reduce the postprandial glucose levels. However, the principle compounds responsible for the inhibitory action of α-amylase and α-glucosidase need to be further identified and characterized. This may be useful for the development of new antidiabetic agents from native plant resources.


Authors are thankful to KLE University and Principal, KLE University's College of Pharmacy, Belagavi for providing the necessary facilities to carry out the work. We are thankful to VGST, Department of IT, BT, and SandT, Government Karnataka for financial support under VGST-CISE scheme. Authors are also thankful to Dr. Subarna Roy, Scientist D, RMRC (ICMR) Belgaum for the valuable support to our research work.

Financial Support and Sponsorship


Conflicts of Interest

There are no conflicts of interest.

 » References Top

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Shai LJ, Magano SR, Lebelo SL, Mogale AM. Inhibitory effects of five medicinal plants on rat alpha-glucosidase: Comparison with their effects on yeast alpha-glucosidase. J Med Plant Res 2011;5:2863-67.  Back to cited text no. 12
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Saha D, Ghosh SK, Das T, Rahman H. Effect of Adiantum caudatumin streptozotocin-induceddiabetes mellitus in rats. Int Res J Pharm Appl Sci 2011;1:9-15.  Back to cited text no. 17
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  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]

  [Table 1], [Table 2]

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14 Screening for potential novel probiotic Levilactobacillus brevis RAMULAB52 with antihyperglycemic property from fermented Carica papaya L.
Navya Sreepathi, V. B. Chandana Kumari, Sujay S. Huligere, Abdel-Basit Al-Odayni, Victor Lasehinde, M. K. Jayanthi, Ramith Ramu
Frontiers in Microbiology. 2023; 14
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15 Inhibition of carbohydrate hydrolyzing enzymes by a potential probiotic Levilactobacillus brevis RAMULAB49 isolated from fermented Ananas comosus
Reshma Mary Martiz, Chandana Kumari V. B., Sujay S. Huligere, Mohd Shahnawaz Khan, Nouf Omar Alafaleq, Saheem Ahmad, Firoz Akhter, Navya Sreepathi, Ashwini P., Ramith Ramu
Frontiers in Microbiology. 2023; 14
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16 Zein as an Effective Carrier for Hesperidin Delivery Systems with Improved Prebiotic Potential
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Molecules. 2023; 28(13): 5209
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17 In vitro Assessment of the Antidiabetic Activity of Aqueous and Ethanolic Extracts from the Aerial Parts of Ajuga orientalis L.
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18 Efficient one-pot synthesis of arylated pyrazole-fused pyran analogs: as leads to treating diabetes and Alzheimer's disease
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19 Binary ethanol-water solvents affect betalain contents and health-promoting properties of red Celosia argentea inflorescence extracts
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International Food Research Journal. 2022; 29(1): 67
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20 Comparison of Herbal formulation and Herbal extracts of seeds and fruits of selected medicinal plants for Antidiabetic Enzyme Inhibitory Studies
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Research Journal of Pharmacy and Technology. 2022; : 4789
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21 Haskap Berry Leaves (Lonicera caerulea L.)—The Favorable Potential of Medical Use
Szymon Sip, Anna Sip, Piotr Szulc, Judyta Cielecka-Piontek
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22 Assisted Extraction with Cyclodextrins as a Way of Improving the Antidiabetic Activity of Actinidia Leaves
Szymon Sip, Anna Gosciniak, Piotr Szulc, Jaroslaw Walkowiak, Judyta Cielecka-Piontek
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23 In Vitro Anti-Diabetic Activities and UHPLC-ESI-MS/MS Profile of Muntingia calabura Leaves Extract
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24 Biological Evaluation, Phytochemical Screening, and Fabrication of Indigofera linifolia Leaves Extract-Loaded Nanoparticles
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25 Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of Plectranthus ecklonii Constituents
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26 Potential for Prebiotic Stabilized Cornus mas L. Lyophilized Extract in the Prophylaxis of Diabetes Mellitus in Streptozotocin Diabetic Rats
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27 In Vitro Antioxidant and Alpha-glucosidase Inhibition Activity of Polygonatum verticillatum of Karnali, Nepal
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28 a-Glucosidase and a-Amylase Inhibition Study and In Silico Analysis of Mimosa pudica L. of Nepalese Origin
Dipesh Shrestha, Tamlal Pokhrel, Kamal Dhakal, Anisha Pandey, Prabha Sharma, Sima Sapkota, Achyut Adhikari
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29 Investigation of phenolic compounds, in vitro antioxidant and enzyme inhibition activities of methanol and aqueous extracts of different parts of Glaucosciadium cordifolium
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30 Antioxidant and enzyme inhibition activities of Spartium junceum with HPLC-DAD profiling
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Emerging Materials Research. 2022; 11(4): 1
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31 Effects of age and food processing of sapodilla leaves for botanical beverage application
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32 Antidiabetic, angiotensin-converting enzyme inhibitory and anti-inflammatory activities of fermented camel milk and characterisation of novel bioactive peptides from lactic-fermented camel milk with molecular interaction study
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33 Design, synthesis, spectroscopic characterization, computational analysis, and in vitro a-amylase and a-glucosidase evaluation of 3-aminopyridin-2(1H)-one based novel monothiooxamides and 1,3,4-thiadiazoles
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34 In Silico Analysis of PTP1B Inhibitors and TLC-MS Bioautography-Based Identification of Free Radical Scavenging and a-Amylase Inhibitory Compounds from Heartwood Extract of Pterocarpus marsupium
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35 Hibiscus sabdariffa L. polyphenolic-rich extract promotes muscle glucose uptake and inhibits intestinal glucose absorption with concomitant amelioration of Fe 2+ -induced hepatic oxidative injury
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36 Exploring the potential of Lacticaseibacillus paracasei M11 on antidiabetic, anti-inflammatory, and ACE inhibitory effects of fermented dromedary camel milk ( Camelus dromedaries ) and the relea
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37 Regulatory effects and anti-inflammatory activity of Trachyspermum ammi (L.) Sprague seeds extract on alleviation of kidney injury in diabetic rats
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38 Evaluation of the biological activities of ß -glucan isolated from Lentinula edodes
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39 Ameliorating Effect of Malva neglecta Wallr on Obesity and Diabetes in Wistar Rats: A Mechanistic Study
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40 Comparative Analysis of the Antioxidant and Antidiabetic Potential of Nelumbo nucifera Gaertn. and Nymphaea lotus L. var. pubescens (Willd.)
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41 HPLC Analysis and Antimicrobial, Antidiarrheal and Antihyperglycemic Properties of Eurya acuminata along with in silico Profiles
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42 Comparative evaluation of in vitro antioxidant and antidiabetic potential of five ethnomedicinal plant species from Punjab, India
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43 In silico profiling of analgesic and antihyperglycemic effects of ethanolic leaves extract of Amischotolype mollissima: evidence from in vivo studies
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44 Comparative Analysis of In Vitro Enzyme Inhibitory Activities and Phytochemicals from Platycladus orientalis (L.) Franco via Solvent Partitioning Method
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45 In silico profiling of analgesic, antidiarrheal and antihyperglycemic properties of Tetrastigma bracteolatum (Wall.) leaves extract supported by in vivo studies
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46 Assessment of in vitro anti-inflammatory, antioxidant and antidiabetic activities of Solanum khasianum Clarke
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47 Comparative evaluation of antioxidant, antiglycation and a-glucosidase inhibitory potential of some indigenous medicinal Trigonella species
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48 Recent developments in dairy kefir-derived lactic acid bacteria and their health benefits
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49 Recent advances in interactions between polyphenols and plant cell wall polysaccharides as studied using an adsorption technique
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50 Effect of different cooking methods on the nutrient, and subsequent bioaccessibility and biological activities in Boletus auripes
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51 Phytofabrication of cost-effective selenium nanoparticles from edible and non-edible plant materials of Senna auriculata: Characterization, antioxidant, antidiabetic, antimicrobial, biocompatibility, and wound healing
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52 Proximate composition, dietary fibre, beta-glucan content, and inhibition of key enzymes linked to diabetes and obesity in cultivated and wild mushrooms
Kansuda Wunjuntuk, Mehraj Ahmad, Taweesak Techakriengkrai, Rangsita Chunhom, Euaphorn Jaraspermsuk, Akkarapol Chaisri, Rujira Kiwwongngam, Siriluk Wuttimongkolkul, Somsri Charoenkiatkul
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53 Extraction of phytochemicals with health benefit from Peperomia pellucida (L.) Kunth through liquid-liquid partitioning
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54 Ameliorative effect of Annona reticulata L. leaf extract on antihyperglycemic activity and its hepato-renal protective potential in streptozotocin induced diabetic rats
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55 Extrusion improves the phenolic profile and biological activities of hempseed (Cannabis sativa L.) hull
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56 Preliminary investigation on chemical composition and bioactivity of differently obtained extracts from Symphytum aintabicum Hub.- Mor. &Wickens
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57 Enzyme inhibition and antioxidant functionality of eleven Inula species based on chemical components and chemometric insights
Ramazan Ceylan, Gokhan Zengin, Mohamad Fawzi Mahomoodally, Kouadio Ibrahime Sinan, Gunes Ak, Sharmeen Jugreet, Oguz Cakir, Rayene Ouelbani, Mehmet Yavuz Paksoy, Mustafa Abdullah Yilmaz
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58 Protective effect of Basella alba leaf against diabetic nephropathy in rats
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59 Ameliorative effect of rubiadin-loaded nanocarriers in STZ-NA-induced diabetic nephropathy in rats: formulation optimization, molecular docking, and in vivo biological evaluation
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60 Hypoglycaemic, antioxidative and phytochemical evaluation of Cornus mas varieties
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61 Phospholipid and n-alkane composition, anti-a-glucosidase and anti-cyclooxygenase activities of milk thistle oil
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62 Synthesis of 1,2,3,triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro a-glucosidase enzyme inhibition studies
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63 Nutritional composition, biological activities, and cytotoxicity of the underutilized fruit of Eleiodoxa conferta
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64 Imidazole Appended Novel Phenoxyquinolines as New Inhibitors of a-Amylase and a-Glucosidase Evidenced with Molecular Docking Studies
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65 A pharmacological perspective of banana: implications relating to therapeutic benefits and molecular docking
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66 Butanol fraction of Alstonia boonei De Wild. leaves ameliorate oxidative stress and modulate key hypoglycaemic processes in diabetic rats
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67 The Global Amylase Research Trend in Food Science Technology: A Data-Driven Analysis
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68 Phytochemical, antimicrobial, antioxidant and enzyme inhibitory potential of medicinal plant Dryopteris ramosa (Hope) C. Chr.
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69 Effect of extrusion technology on hempseed ( Cannabis sativa L .) oil cake: Polyphenol profile and biological activities
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70 Türkiye’de Yetisen Campanula lyrata Lan. subsp. lyrata’nin Enzim Inhibe Edici Etkilerinin ve Antioksidan Aktivitelerinin Belirlenmesi
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71 a-Glucosidase and a-Amylase Inhibition of Some Ethanolic Propolis Samples
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72 Fermentation of Jamaican Cherries Juice Using Lactobacillus plantarum Elevates Antioxidant Potential and Inhibitory Activity against Type II Diabetes-Related Enzymes
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73 Antioxidant, Anti-Inflammatory, and Anti-Diabetic Activity of Phenolic Acids Fractions Obtained from Aerva lanata (L.) Juss.
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74 Development and Characterization of Novel Biopolymer Derived from Abelmoschus esculentus L. Extract and Its Antidiabetic Potential
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75 Inhibition of the in vitro Activities of a-Amylase and Pancreatic Lipase by Aqueous Extracts of Amaranthus viridis, Solanum macrocarpon and Telfairia occidentalis Leaves
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76 Traditional Uses, Nutritional and Pharmacological Potentials of Clerodendrum volubile
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Plants. 2021; 10(9): 1893
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77 Beneficial Health Potential of Algerian Polysaccharides Extracted from Plantago ciliata Desf. (Septentrional Sahara) Leaves and Seeds
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78 The infusion of goji berries and red dates ameliorates the overall qualities of kenaf leaves tea
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79 Lipid Extracts from Caulerpa lentillifera Waste: An Alternative Product in a Circular Economy
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80 In-vitro anti-diabetic activity and in-silico studies of binding energies of palmatine with alpha-amylase, alpha-glucosidase and DPP-IV enzymes
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81 Pharmacological Properties and Chemical Profiles of Passiflora foetida L. Extracts: Novel Insights for Pharmaceuticals and Nutraceuticals
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82 Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of Salvia aurita Constituents
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83 Screening for toxicological and anti-diabetic potential of n-hexane extract ofTapinanthus bangwensisleaves
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84 Synthesis, Characterization, Biological Evaluation and Molecular Docking Studies of Some Oxazinyl-Thiazolidinone Derivatives
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85 Bioactive lipids, antibacterial, hypoglycaemic, and antioxidant potentials of immature and mature Vicia faba L. seeds cultivated in tunisia
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86 UHPLC-QTOF-MS/MS metabolites profiling and antioxidant/antidiabetic attributes of Cuscuta reflexa grown on Casearia tomentosa: exploring phytochemicals role via molecular docking
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87 Assessment of the antioxidant and enzyme inhibition activities of Cousinia iconica with focus on phytochemical investigation by LC-MS/MS
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88 Inhibitory effect of roasted/ unroasted Argania spinosa seeds oil on a- glucosidase, a-amylase and intestinal glucose absorption activities
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89 a-Glucosidase inhibitors from Duranta repens modulate p53 signaling pathway in diabetes mellitus
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90 Nutritional composition and biological activities of the edible shoots of Bambusa vulgaris and Gigantochloa ligulata
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91 Gene set enrichment analysis of a-amylase and a-glucosidase inhibitors of Cassia glauca
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92 Gene ontology enrichment analysis of a-amylase inhibitors from Duranta repens in diabetes mellitus
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93 Integration of in silico, in vitro and ex vivo pharmacology to decode the anti-diabetic action of Ficus benghalensis L. bark
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94 Photo-assisted bio-fabrication of silver nanoparticles using Annona muricata leaf extract: exploring the antioxidant, anti-diabetic, antimicrobial, and cytotoxic activities
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