| DRUG WATCH |
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| Year : 2014 | Volume
: 46
| Issue : 6 | Page : 657-659 |
Duloxetine-induced hyponatremia in an elderly patient treated with thiazide diuretics
Miyu Mori1, Tetsuro Koide1, Yoshinori Imanishi1, Yuriyo Matsui2, Toru Matsuda2
1 Department of Pharmacy, Kuwana West Medical Center, Kuwana, Japan
2 Department of Orthopaedic Surgery, Kuwana West Medical Center, Kuwana, Japan
Correspondence Address:
Miyu Mori
Department of Pharmacy, Kuwana West Medical Center, Kuwana
Japan
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.144947
Hyponatremia is a known adverse effect of duloxetine, and it can lead to potentially life-threatening complications. Administration of thiazide diuretics also has been the cause of hyponatremia. We report a case of duloxetine-induced hyponatremia in an elderly patient treated with thiazide diuretics. An 86-year-old woman treated with the trichlormethiazide was admitted for vertebral compression fracture with disorientation and nausea on the 6 th day of treatment with duloxetine. Laboratory findings revealed hyponatremia, hypo-osmolality, concentrated urine, and increased urine sodium. Syndrome of inappropriate antidiuretic hormone was considered, therefore, duloxetine, and trichlormethiazide was discontinued and treated with fluid restriction, furosemide and sodium chloride administered orally. Disorientation and nausea were improved after correction of hyponatremia. Health care practitioners should be aware of the possibility of duloxetine-induced hyponatremia, particularly in patients treated with thiazide diuretics.
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