| DRUG WATCH |
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| Year : 2014 | Volume
: 46
| Issue : 6 | Page : 649-650 |
Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy
Kamilia Ksouda1, Hanen Affes1, Rim Atheymen1, Mariem Ezzeddine2, Khaled Zeghal1, Serria Hammami1
1 Department of Pharmacology, School of Medecine of Sfax, Tunisia
2 Department of Rheumatology, CHU Hedi Chaker Sfax, Tunisia
Correspondence Address:
Kamilia Ksouda
Department of Pharmacology, School of Medecine of Sfax
Tunisia
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.144940
Methotrexate (MTX) is one of the most commonly used medicines in the treatment of psoriatic arthritis. The drug can produce steatosis and cirrhosis. Autoimmune hepatitis is a rare and serious adverse effect. We describe the case of a 53-year-old woman who developed autoimmune hepatitis after a long-term use of MTX for psoriatic arthritis. Hepatitis was completely resolved 4 months after stopping this drug. The pathophysiologic mechanisms of a drug-induced autoimmunity are unclear and complex. This report confirms the need to monitor liver enzymes carefully in patients using long-term treatment with MTX for psoriasis or rheumatoid arthritis.
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