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Year : 2014  |  Volume : 46  |  Issue : 6  |  Page : 622-626

The effect of progesterone on systemic inflammation and oxidative stress in the rat model of sepsis

1 Department of Obsterics and Gynecology, Nenehatun Hospital, Erzurum, Turkey
2 Department of Biochemistry, Meram Faculty of Medicine, Konya University, Konya, Turkey
3 Department of Biochemistry, Goverment Hospital of Oltu, Turkey
4 Departments of Anesthesiology and Reanimation, Faculty of Medicine, Atatürk University, Erzurum, Turkey
5 Department of Pharmacology, Faculty of Medicine, Atatürk University, Erzurum, Turkey
6 Department of Biochemistry, Faculty of Medicine, Atatürk University, Erzurum, Turkey

Correspondence Address:
Ayse Nur Aksoy
Department of Obsterics and Gynecology, Nenehatun Hospital, Erzurum
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.144922

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Objectives: To explore the protective effect of progesterone on inflammation and oxidative stress in a rat model of sepsis created by cecal ligation and puncture (CLP). Materials and Methods: Rats were randomly divided into 4 groups: Overiectomy group (OVX), sham operated (control), sepsis (CLP) group and progesterone-treated CLP group (CLP+ progesterone). The rats in CLP+ progesterone group received intraperitoneal progesterone (2 mg/kg). Cardiac blood samples were obtained for the measurement levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Tissue samples, including liver, kidney and uterus of rats were prepared to determine activities of myeloperoxidase (MPO), glutathione peroxidase (GPx) and levels of malondialdehyde (MDA). Results: Increased serum IL-6 and TNF-α levels were found in the CLP group in comparison with the control group (P = 0.01, P = 0.02; respectively). In CLP+ progesterone group, mean MDA concentration of kidney tissue was significantly lower than in CLP group (P = 0.003). Liver MDA concentration of the CLP+ progesterone group was not significantly different from that of the control group. While there were no significant differences among groups regarding liver MPO; in the CLP group, MPO activity in kidney (P = 0.02) and uterine tissues (P = 0.03) were found to be significantly higher compared to the control group. In CLP+ progesterone group, mean MPO activities of all tissues were not different than those of control group. The uterine tissue GPx activity in the CLP+ progesterone group was not statistically significantly different from control group. Conclusions: We suggest that progesterone ameliorates sepsis syndrome by reduction of the inflammatory cytokines IL-6 and TNF-α, and by restoration of antioxidant enzyme activities in some tissues.


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