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 RESEARCH ARTICLE
Year : 2014  |  Volume : 46  |  Issue : 4  |  Page : 413-415

Does tramadol affect coagulation status of patients with malignancy?


1 Department of Anaesthesiology and Reanimation, Eskisehir Osmangazi University Medical School, Eskisehir, Turkey
2 Department of Hematology, Eskisehir Osmangazi University Medical School, Eskisehir, Turkey

Correspondence Address:
Dilek Ceyhan
Department of Anaesthesiology and Reanimation, Eskisehir Osmangazi University Medical School, Eskisehir
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.135954

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Aim: The study investigated the direct effects of tramadol on the coagulation status of women with gynecologic malignancies in vitro. Materials and Methods: Citrated whole-blood samples from 21 patients with gynecologic tumors were spiked ex vivo with 2 or 6 μl/ml tramadol. Thrombelastography (TEG) analysis was performed using ROTEM® to assess clotting time (CT), clot formation time (CFT) and maximum clot formation (MCF). Results: In the INTEM assay, CT (P < 0.05) and CFT (P < 0.01) were significantly prolonged with tramadol at a 6 μl/ml concentration compared with baseline. There were no significant differences in MCF values between the baseline and the tramadol-treated samples (P > 0.05). Blood medicated with tramadol (6 μl/ml) clotted slowly (increased CT and CFT). Conclusion: The changes observed by TEG demonstrated that tramadol impairs hemostasis in a concentration-dependent manner in the whole blood of women with gynecologic malignancies in vitro.






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