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 RESEARCH ARTICLE
Year : 2014  |  Volume : 46  |  Issue : 3  |  Page : 322-327

Effects of Aloe vera leaf gel extract on rat peritonitis model


1 Departments of Pediatrics, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey
2 Division of Pediatric Nephrology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey
3 Department of Biochemistry, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey
4 Department of Internal Medicine, Division of Nephrology, Izmir, Turkey
5 Department of Microbiology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey
6 Department of Pathology, Faculty of Medicine, Ege University, Izmir, Turkey

Correspondence Address:
Ayca Altincik
Departments of Pediatrics, Faculty of Medicine, Adnan Menderes University, Aydin
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.132184

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Objectives: The aim of this study was to investigate the antibacterial, anti-inflammatory, and antioxidant activities and probable toxic effects of Aloe vera (AV) in a rat peritonitis model. Materials and Methods: Rats were divided into five groups: (1) Control group, (2) AV group, (3) peritonitis group (P), (4) peritonitis + AV group (P + AV), and (5) peritonitis + antibiotherapy group (P + Ab). Ultrafiltration (UF) rates were determined and colony and leukocyte counts were calculated in the dialysate. Glucose, blood urea nitrogen (BUN), creatinine levels, and alanine transaminase (ALT) activities were studied in blood. Glucose, interleukins (IL-1β, IL-6), and prostaglandin E2 (PGE2) were studied in dialysate and peritoneal tissue for the assessment of the anti-inflammatory effect. Copper/zinc superoxide dismutase (Cu, Zn-SOD), malondialdehyde (MDA), and nitric oxide (NO) were also investigated in peritoneal tissue. Results: Aloe vera increased the UF rate and lowered leukocyte numbers in the peritonitis group. There was no significant difference in blood and dialysate glucose, BUN, creatinine levels and ALT activity among control and AV groups. AV decreased IL-1β, IL-6 and PGE2 in peritonitis, showing good anti-inflammatory effect. AV showed antioxidant effect on the chosen antioxidant parameters Cu, Zn-SOD, MDA, and NO. Conclusion: It was concluded that, AV might be used in peritonitis for its probable UF increasing, anti-inflammatory, and antioxidant effects.






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