| SHORT COMMUNICATION
|Year : 2014 | Volume
| Issue : 1 | Page : 113-116
Effect of ovarian sex hormones on non-steroidal anti-inflammatory drug-induced gastric lesions in female rats
Tultul K Sangma, Seema Jain, Pramod K Mediratta
Department of Pharmacology, University College of Medical Sciences and Gugu Teg Bahadur Hospital, New Delhi, India
Objective: The objective of the following study is to investigate the effect of ovarian sex hormones on gastric ulcer in female rats.
Materials and Methods: Female rats were treated daily with estrogen (0.05 and 0.1 mg/kg), progesterone (2.0 and 5.0 mg/kg), combined estrogen (0.05 mg/kg) and progesterone (2.0 mg/kg), ranitidine (30 mg/kg) or vehicle for 7 days. Ulcers were induced with aspirin on 7 th day. Four hours later, animals were sacrificed and stomach were removed for macroscopic and biochemical examination.
Results: Estrogen in 0.05 and 0.1 doses showed 32% and 18% of ulcer inhibition, respectively, progesterone 09% and 14% inhibition in 2.0 and 5.0 mg/kg doses, respectively, whereas combined estrogen and progesterone showed 23% and ranitidine showed 60% inhibition. However, the inhibition attained and the stomach malondialdehyde and glutathione levels in sex hormone treated groups were not statistically significant when compared to control group.
Conclusion: At the tested doses, these ovarian sex hormones neither worsen nor protect against aspirin-induced gastric lesions in female rats.
Pramod K Mediratta
Department of Pharmacology, University College of Medical Sciences and Gugu Teg Bahadur Hospital, New Delhi
Source of Support: None, Conflict of Interest: None
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