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Year : 2013  |  Volume : 45  |  Issue : 5  |  Page : 458-463

Effect of carvedilol on cardiomyocyte apoptosis in a rat model of myocardial infarction: A role for toll-like receptor 4

1 Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China
2 Faculty of Health and Medical Sciences, Division of Biochemistry and Physiology, University of Surrey, Guildford, GU2 7XH, United Kingdom

Correspondence Address:
Yan Xu
Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022
PR China
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Source of Support: This work was supported by Anhui Provincial Natural Science Foundation (number: 070413103) and by Anhui Provincial Bureau of Education Natural Science Foundation (number: KJ2009A036Z), PR China, Conflict of Interest: None

DOI: 10.4103/0253-7613.117729

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Objectives: Toll-like receptor 4 (TLR4) is crucial in cardiomyocyte apoptosis induced by myocardial infarction (MI) and carvedilol has been reported to have anti-apoptotic effects. We hypothesized that the effects of this agent are in part mediated through TLR4 signaling pathways. Materials and Methods: A total of 48 rats were randomized to the following groups before surgery: sham-operated group (n = 8), MI group (n = 10) and three carvedilol-treatment groups (n = 30, 2 mg/kg, 10 mg/kg and 30 mg/kg). Sham and MI groups were given vehicle and carvedilol groups received different dose carvedilol, by direct gastric gavage for 7 days. On the 4 th day of drug or vehicle administration, MI model was produced by ligating the left anterior descending coronary artery. On day 3 after MI, apoptosis was assessed by TdT-UTP nick-end assay; the levels of expression of Bax, Bcl-2, TLR4 and nuclear factor-κB (NF-κB) in infarcted myocardium were analyzed by immunohistochemistry. Results: Carvedilol ameliorated MI-induced apoptosis in a dose-dependent manner. In parallel, carvedilol also decreased the ratio of Bax to Bcl-2, the expression of TLR4 and NF-κB induced by MI. The extent of apoptosis and Bax-Bcl-2 ratio was strongly correlated with the TLR4 levels. Conclusion: This study suggests that the short-term administration of carvedilol can significantly alleviate cardiomyocyte apoptosis in the infarcted myocardium probably by inhibiting the excessive expression of TLR4 and NF-κB induced by infarction.


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