| RESEARCH ARTICLE
|Year : 2013 | Volume
| Issue : 4 | Page : 381-385
Cytotoxic activity of aqueous extracts of Anogeissus leiocarpus and Terminalia avicennioides root barks against Ehrlich Ascites Carcinoma cells
Amadu Kayode Salau1, Musa Toyin Yakubu2, Adenike Temidayo Oladiji2
1 Phytomedicine Research Laboratory, Biochemistry and Nutrition Unit, Department of Chemical Sciences, Fountain University, Osogbo, Nigeria
2 Phytomedicine, Reproductive Biochemistry and Toxicology Research Laboratory, Department of Biochemistry, University of Ilorin, Ilorin, Nigeria
Objectives: Folkloric claims on the use of a mixture of Anogeissus leiocarpus and Terminalia avicennioides root barks in tumor management exist without scientific evidence. This study aimed at investigating the phytochemical constituents and in vitro antiproliferative activity of these plants and their mixture.
Materials and Methods: Phytochemical screening was carried out on the aqueous extracts after which various concentrations (0 to 1 000 μg/ml) were incubated with Ehrlich ascites carcinoma cell lines for 3 and 24 hours.
Results: The extracts contained alkaloids, tannins, flavonoids, phenolics, saponins, phlobatannins, and terpenes. The separate extracts and their 1:1 mixture significantly (P<0.05) decreased the computed percentage viability of the cell lines in a dose- and time-dependent manner.
Conclusions: The antiproliferative activity may be due to the presence of the bioactive compounds in the extracts and has a potential in the management of tumor.
Amadu Kayode Salau
Phytomedicine Research Laboratory, Biochemistry and Nutrition Unit, Department of Chemical Sciences, Fountain University, Osogbo
Source of Support: None, Conflict of Interest: None
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