| RESEARCH ARTICLE
|Year : 2013 | Volume
| Issue : 4 | Page : 330-333
Pharmacokinetics of single-dose primaquine in patients with chronic kidney dysfunction
Shaunak P Kulkarni1, Sanjana R Shah1, Prashant P Kadam1, Kannan Sridharan1, Nivrutti K Hase2, Partha P Shetty2, Urmila M Thatte1, Nithya J Gogtay1
1 Department of Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
2 Department of Nephrology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
Aim: The pharmacokinetics of primaquine has not been studied in special populations. Being a basic compound, preferential binding to alpha-1 acid glycoprotein and substrate for P-glycoprotein, may predispose the drug for an altered pharmacokinetics in states of renal dysfunction. This study attempts to evaluate the pharmacokinetics of a single oral dose (15 mg) of primaquine in severely impaired renal function and end stage renal dysfunction patients compared to healthy participants.
Materials and Methods: Twelve patients each with chronic kidney disease classified as either Stage IV or V (not on dialysis) were recruited. Data from 12 healthy participants was used as concurrent controls. Serial blood collections were performed following a single dose 15 mg Primaquine orally. Primaquine concentrations were measured in the plasma using a validated HPLC method.
Results: The C max [median (range) in ng/ml] was 29.3 (14.6-104.3), 40.3 (14.8 - 78.6), and 49.8 (15 - 169.6) and the t max [median (range) in hours] was 3.0 (1.0- 6.0), 2.0 (1.5 - 8) and 2.0 (1.0 - 4.0) for healthy and stage IV, V (not on dialysis) CKD participants, respectively. No statistically significant difference was observed in any of the pharmacokinetic parameters between healthy, stage IV and V CKD participants.
Conclusion: Pharmacokinetics of single oral dose primaquine (15 mg) does not appear to be altered in patients with severely impaired renal function and end stage renal dysfunction. A change in dose or frequency of the drug administration perhaps may not be required in this population.
Nithya J Gogtay
Department of Pharmacology, Seth GS Medical College and KEM Hospital, Parel, Mumbai
Source of Support: None, Conflict of Interest: None
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