| SHORT COMMUNICATION |
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| Year : 2013 | Volume
: 45
| Issue : 3 | Page : 283-285 |
Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari
Youqing Tian1, Shengtang Ma2, Biqi Lin3, Junping Kou2, Boyang Yu2
1 Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing; Lianyungang TCM Branch, Jiangsu Union Vocational Technical Institute, Lianyungang; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
2 Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
3 Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, China
Correspondence Address:
Boyang Yu
Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing
China
 Source of Support: This work was supported by the Major National
Science and Technology Project of China for Significant New Drugs
Development (No. 2009ZX09103-308 and 2012ZX09102201-015),
and A Project Funded by the Priority Academic Program Development
of Jiangsu Higher Education Institutions. (We have described these
foundations in acknowledgements)., Conflict of Interest: No  | Check |
DOI: 10.4103/0253-7613.111896
Objective: To investigate the anti-thrombotic activity of DT-13 in experimental animal models.
Materials and Methods: The anti-thrombotic activity of DT-13 was evaluated by measuring the thrombus induced by inferior vena cava (IVC) ligation in mice and rats. The anti-thrombotic mechanism of DT-13 was investigated by assessing the mRNA expression levels of interleukin-6 (IL-6) and tissue factor (TF) in rat IVC tissue around thrombus.
Results: DT-13 markedly inhibited thrombosis induced by IVC ligation for 6 h in mice (2.0 and 4.0 mg/kg, p.o.) and for 18 h in rats (1.4 mg/kg, p.o.). Furthermore, DT-13 down-regulated the increased mRNA expression levels of IL-6 and TF in rats.
Conclusions: DT-13 has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of IL-6 and TF.
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