| RESEARCH ARTICLE |
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| Year : 2013 | Volume
: 45
| Issue : 3 | Page : 248-251 |
Anxiolytic-like effect of (4-benzylpiperazin-1-yl)(3-methoxyquinoxalin-2-yl)methanone (6g) in experimental mouse models of anxiety
Shvetank Bhatt, Radhakrishnan Mahesh, Thangaraj Devadoss, Ankur Kumar Jindal
Department of Pharmacy, Birla Institute of Technology & Science, Pilani, Rajasthan, India
Correspondence Address:
Shvetank Bhatt
Department of Pharmacy, Birla Institute of Technology & Science, Pilani, Rajasthan
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0253-7613.111923
Aim: The present study was designed to investigate the anxiolytic activity of 6g, a novel serotonin type-3 receptor (5-HT 3 ) receptor antagonist in experimental mouse models of anxiety.
Materials and Methods: The anxiolytic activity of "6g" (1 and 2 mg/kg, intraperitoneally [i.p.]) was evaluated in mice by using a battery of behavioral tests of anxiety such as elevated plus maze (EPM), light-dark (L&D) box, hole board (HB), and open field test (OFT) with diazepam (2 mg/kg, i.p.) as standard anxiolytic. None of the tested dose of "6g" affects the base line locomotion.
Results: The new chemical entity "6g" (2 mg/kg, i.p.) and diazepam (2 mg/kg, i.p.) significantly (P < 0.05) increased the percentage of time spent and number of entries in open arm in the EPM test. In the L&D test compound "6g" (2 mg/kg, i.p.) and diazepam (2 mg/kg, i.p.) significantly (P < 0.05) increased the total time spent in light compartment as well as number of transitions from one compartment to other. Compound "6g" (1 and 2 mg/kg, i.p.) and diazepam (2 mg/kg, i.p.) also significantly (P < 0.05) increased number of head dips, whereas significantly (P < 0.05) decreased the head dipping latency in HB test as compared to vehicle control group. In addition, 6g (2 mg/kg, i.p.) and diazepam (2 mg/kg, i.p.) significantly (P < 0.05) increased the ambulation scores (square crossed) in OFT and there was no significant effect of 6g (1 and 2 mg/kg, i.p.) and diazepam (2 mg/kg, i.p.) on rearing scores.
Conclusion: In conclusion, these findings indicated that compound "6g" exhibited an anxiolytic-like effect in animal models of anxiety.
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