| RESEARCH ARTICLE
|Year : 2013 | Volume
| Issue : 3 | Page : 223-226
Comparative evaluation of aqueous and plasma concentration of topical moxifloxacin alone and with flurbiprofen in patients of cataract
Sujash Halder1, Kanchan Kumar Mondal2, Supreeti Biswas3, Tapan Kumar Mandal4, Bakul Kumar Dutta4, Mithilesh Haldar5
1 Department of Pharmacology, Malda Medical College, Malda, India
2 Department of Ophthalmology, R.G. Kar Medical College, Kolkata, India
3 Department of Pharmacology, Burdwan Medical College, Burdwan, India
4 Department of Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences (WBUAFS), Kolkata, India
5 Department of Pharmacology, R.G. Kar Medical College, Kolkata, India
Objectives: To determine the aqueous and plasma concentrations of moxifloxacin administered topically alone and with flurbiprofen in patients undergoing cataract surgery.
Materials and Methods: A total of 50 subjects scheduled for routine cataract surgery were randomly allocated to two groups (n = 25 each). Group-1 patients were treated with topical moxifloxacin alone: One drop 6 times/day for 3 days before surgery and one drop 4 times on the day of surgery: Group-2 patients were treated with topical moxifloxacin as in Group-1 and with topical flurbiprofen: One drop 4 times/day for 3 days before and on the day of surgery. The interval between two drugs was 30 min for last 3 days and 15 min on the day of surgery. Last dose was administered 1 h before aqueous humor and blood sampling for both the groups. The antibiotic concentration in aqueous humor and plasma were determined by using high performance liquid chromatography.
Results: The mean concentration of moxifloxacin in aqueous humor was 1.71 ± 0.82 mg/ml in Group-1 and 2.39 ± 1.34 mg/ml in Group-2. Concentrations of moxifloxacin in aqueous humor were significantly higher in Group-2 than that of Group-1.
Conclusion: Flurbiprofen may increase the concentration of moxifloxacin in aqueous humor.
Department of Pharmacology, Malda Medical College, Malda
Source of Support: None, Conflict of Interest: None
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