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Year : 2013  |  Volume : 45  |  Issue : 1  |  Page : 83-86

Peritoneal mast cell stabilization potential of Pothos scandens L.


1 Department of Pharmacognosy, J.S.S. College of Pharmacy, Ootacamund, Tamil Nadu, India
2 Department of Pharmacology, J.S.S. College of Pharmacy, Ootacamund, Tamil Nadu, India

Correspondence Address:
Saurabh Gupta
Department of Pharmacognosy, J.S.S. College of Pharmacy, Ootacamund, Tamil Nadu
India
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Source of Support: Authors are grateful to JSS College of Pharmacy and JSS University, Mysore for kind support., Conflict of Interest: None


DOI: 10.4103/0253-7613.106442

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Objective: To investigate the peritoneal mast cell stabilization activity of Pothos scandens extracts Materials and Methods: Pothos scandens L. (family- Araceae) aerial part was successively extracted with ethanol and aqueous to prepare extract of the plant. The extracts of P. scandens were evaluated for stabilization of mast cell in rat allergic models. The extract of P. scandens ethanolic, 50% aqueous ethanolic and aqueous (1, 10 and 100 μg/ml) was studied for peritoneal mast cell stabilization activity in rat mesenteric preparation induced by C 48/80. Result: Preliminary phytochemical analysis revealed the presence of carbohydrates, fixed oil, proteins, alkaloids, glycosides, flavonoids and phenolic compounds. The ethanolic, 50% aqueous ethanolic and aqueous extracts of P. scandens L. showed dose dependent increase in the number of intact cells when compare with C48/80 at the concentration of 10 and 100 μg/ml. It virtues further work towards the isolation of phytoconstituents from this plant. Conclusion: This finding provides evidence that the P. scandens L. inhibits mast cell-derived immediate-type allergic reactions and mast cell degranulation. P. scandens has a potential as allergic anti- asthmatic agent.






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