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 RESEARCH ARTICLE
Year : 2012  |  Volume : 44  |  Issue : 5  |  Page : 566-570

Effect of methanolic fraction of Kalanchoe crenata on metabolic parameters in adriamycin-induced renal impairment in rats


1 Laboratory of Endocrinology and Radioisotopes, Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaoundé; General Endocrinology and Metabolism Systems (GEMS), Laboratory of Animal Physiology, Faculty of Science, Yaoundé, Cameroon
2 General Endocrinology and Metabolism Systems (GEMS), Laboratory of Animal Physiology, Faculty of Science, Yaoundé, Cameroon
3 Laboratory of Endocrinology and Radioisotopes, Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaoundé; Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
4 Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

Correspondence Address:
René Kamgang
Laboratory of Endocrinology and Radioisotopes, Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaoundé; General Endocrinology and Metabolism Systems (GEMS), Laboratory of Animal Physiology, Faculty of Science, Yaoundé
Cameroon
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.100374

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Objectives: To investigate the effect of Kalanchoe crenata methanolic fraction (MEKC) on proteinuria, glucosuria, and some other biochemical parameters in adriamycin-induced renal impairment in rats. Materials and Methods: Ether anesthetized rats received three intravenous injections (days 0, 14, and 28) of 2 mg/kg body weight of adriamycin. Repeated doses of the extract (0, 50, and 68 mg/kg b.w.) and losartan (10 mg/kg b.w.) were administered orally once daily, for 6 weeks, to these rats. Kidney functions were assessed through biochemical parameters. Results: MEKC decreased proteinuria and also the urinary excretion of creatinine, glucose, and urea significantly in diseased rats. A decrease in serum levels of creatinine, urea, potassium, alkaline phosphatase, conjugate bilirubin, and alanine transaminase level was also recorded in nephropathic rats, but plasma levels of uric acid and glucose remained unchanged. Moreover, the plant extract markedly (P < 0.05) increased plasma sodium and decreased (P < 0.01) the urinary sodium and potassium levels. Conclusions: The results indicated that the treatment with the methanolic fraction of K. crenata may improve proteinuria and all other symptoms due to adriamycin-induced nephropathy and, more than losartan, could ameliorate kidney and liver functions. K. crenata could be a potential source of new oral antinephropathic drug.






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