| RESEARCH ARTICLE
|Year : 2012 | Volume
| Issue : 3 | Page : 314-318
The effect of inhaled corticosteroids on hypothalamic-pituitary-adrenal axis
Keivan Gohari Moghaddam1, Negin Rashidi1, Hamidreza Aghaei Meybodi2, Nader Rezaie1, Mahdi Montazeri1, Ramin Heshmat2, Zohreh Annabestani2
1 Department of Pulmonology, Tehran University of Medical Science (TUMS), Tehran, Iran
2 Department of Endocrinology and Metabolism Research Center (EMRC), Tehran University of Medical Science (TUMS), Tehran, Iran
Objectives: The aim of this study was to compare systemic effects of high-dose fluticasone propionate (FP) and beclomethasone dipropionate (BDP) via pressurized metered dose inhaler on adrenal and pulmonary function tests.
Materials and Methods: A total of 66 patients with newly diagnosed moderate persistent asthma without previous use of asthma medications participated in this single blind, randomized, parallel design study. FP or BDP increased to 1 500 μg/d in 62 patients who had not received oral or IV corticosteroids in the previous six months. Possible effects of BDP and FP on adrenal function were evaluated by free cortisol level at baseline and after Synacthen test (250 μg). Fasting plasma glucose and pulmonary function tests were also assessed. Similar tests were repeated 3 weeks after increasing dose of inhaled corticosteroids to 1 500 μg/d.
Results: No statistically significant suppression was found in geometric means of cortisol level post treatment in both groups. After treatment in FP group, mean forced expiratory volume in one second (FEV1) and mean forced vital capacity (FVC) values improved by 0.17 l (5.66% ± 13.91, P=0.031) and 0.18 l (5.09% ± 10.29, P=0.010), respectively. Although FEV1 and FVC improved in BDP group but was not statistically significant. Oral candidiasis and hoarseness were observed in 6.5% patients receiving BDP, but hoarseness was found in 3.2% patients in FP group (P=0.288).
Conclusions: The results indicate that safety profiles of high doses of BDP and FP with respect to adrenal function are similar, but FP is more efficacious than that of BDP in improving pulmonary function test.
Department of Pulmonology, Tehran University of Medical Science (TUMS), Tehran
Source of Support: Study was financially supported by Endocrinology and Metabolism Research Center (EMRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran, Conflict of Interest: None
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