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 RESEARCH ARTICLE
Year : 2012  |  Volume : 44  |  Issue : 2  |  Page : 184-188

Effect of phenolic acids on functions of rat aorta, vas deferens and on metabolic changes in streptozotocin-induced diabetes


Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Tepebasi TR 26470, Eskisehir, Turkey

Correspondence Address:
Nurcan Bektas
Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Tepebasi TR 26470, Eskisehir
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.93845

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Objectives: This study aimed to investigate the effects of antioxidant treatment on streptozotocin (STZ)-induced diabetic metabolic and smooth muscle (SM) complications in rats. Materials and Methods: Threeweeks after STZ injection (i.v.), vehicle, p-OH benzoic (p-OHBA), protocatechic (PA) and gallic acids (GA) were separately administered (10 mg/kg each, i.p.) to the rats everyday for 3 weeks. Metabolic functions were observedregularly. The rats in all groups were sacrificed andaorta and Vas deferens were dissected. Theresponses of isolated organs to agonists (acetylcholine and phenylephrine) were recorded. Results: Protocatechic acid prevented increase in food consumption and feces output significantly. The responses of isolated organs to agonists increased in the STZ-diabetic rats. The test drugs either prevented, exacerbated or didnot affect the SMchanges in the STZ-diabetic rats. Conclusions: It was concluded that p-OHBA, PA and GA may cause effects independently of their antioxidant effect and/or of diabeticcomplications. They may exhibit pro-oxidant activities in the experimental conditions applied.






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