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 » Introduction
 »  Materials and Me...
 » Results
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 Table of Contents    
Year : 2012  |  Volume : 44  |  Issue : 1  |  Page : 73-77

Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats

1 Department of Pharmacology, K.L.E. Society's College of Pharmacy, Hubli, India
2 Department of Pharmacology, Guttal Ayurvedic Medical College, Dharwad, Karnataka, India

Date of Submission22-Feb-2011
Date of Decision06-Apr-2011
Date of Acceptance18-Oct-2011
Date of Web Publication14-Jan-2012

Correspondence Address:
Agadihiremath Viswanatha Swamy
Department of Pharmacology, K.L.E. Society's College of Pharmacy, Hubli
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7613.91871

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 » Abstract 

Objectives: To study the preventive role of curcumin against doxorubicin (Dox)-induced myocardial toxicity in rats.
Materials and Methods: Cardiotoxicity was produced by cumulative administration of Dox (15 mg/kg for two weeks). Curcumin (200 mg/kg, po) was administered as pretreatment for two weeks and then for two alternate weeks with Dox. The general observations, mortality, histopathology, biomarker enzymes like lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), biochemical parameters such as aspartate aminotransferase (AST) alanine aminotransferase (ALT) and alkaline phosphatase (ALP), antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were monitored after three weeks of last dose.
Results: The repeated administration of Dox induced cardiomyopathy associated with an antioxidant deficit and increased level biomarkers. Pretreatment with the curcumin significantly protected myocardium from the toxic effects of Dox by reducing the elevated level of biomarker enzymes like LDH and CPK and biochemical parameters such as AST, ALT and ALP back to normal. Curcumin increased the reduced level of GSH, SOD and CAT and decreased the elevated level of malondialdehyde (MDA) in cardiac tissue.
Conclusion: The biochemical and histopathology reports support the cardioprotective effect of curcumin which could be attributed to antioxidant.

Keywords: Antioxidant, cardiotoxicity, curcumin, doxorubicin, free radicals

How to cite this article:
Swamy AV, Gulliaya S, Thippeswamy A, Koti BC, Manjula DV. Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats. Indian J Pharmacol 2012;44:73-7

How to cite this URL:
Swamy AV, Gulliaya S, Thippeswamy A, Koti BC, Manjula DV. Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats. Indian J Pharmacol [serial online] 2012 [cited 2023 Dec 8];44:73-7. Available from: https://www.ijp-online.com/text.asp?2012/44/1/73/91871

 » Introduction Top

Doxorubicin/adriamycin (Dox) is a powerful, well-established and highly efficacious drug in many kinds of cancers like solid tumors, leukemia, soft tissue sarcoma, breast cancer, small cell carcinoma of the lung and esophageal carcinomas. But its clinical usefulness is still restricted due to its specific toxicities to cardiac tissues. [1] Congestive heart failure, cardiomyopathy, and electrocardiographic changes were demonstrated after cumulative Dox administration. [2] The possible mechanisms proposed for cardiotoxic effects of Dox include free radical induced myocardial injury, lipid peroxidation, [3] mitochondrial damage, [4] decreased activity of Na + -K + adenosine triphosphate, [5] vasoactive amine release [6] and cellular toxicity. [7] Increased oxidative stress [8] and release of free radicals, including super oxide anion (O 2- ) and other reactive oxygen intermediates as well as endogenous antioxidant deficits have been suggested to play a major role in Dox-induced cardiomyopathy and heart failure. [9] Our earlier studies have demonstrated that polyherbal formulation/antioxidant compounds show protective effects in Dox-induced cardiotoxicity, [10] without reducing their therapeutic efficacy. Moreover, in recent years, it has been observed that there is a growing interest in the usage of natural antioxidants as a protective strategy against cardiovascular-related problems in experiments such as ischemia reperfusion [11] and Dox-induced cardiotoxicity. [12]

Curcumin (Cur), a yellow pigment obtainable from the rhizomes of the plant Curcuma longa, is a crystalline compound that has been traditionally used in medicine and culinary practices in India. Recently, curcumin was found to possess chemopreventive effect against skin cancer, forestomach cancer, colon cancer and oral cancer in mice. It possesses various pharmacological effects viz antioxidant, anti-inflammatory, anti-thromobotic, anti-apoptotic and hepatoprotective. Review of literature reveals that curcumin shows protective role against isoproterenol-induced myocardial infarction [13] and reperfusion-induced myocardial injuries in rats. [14] The non-toxic nature of curcumin [15] as well as its multiple beneficial effects has made it one of the most attractive compounds to explore for its protective role. Therefore, the present attempt has been made to investigate the role of curcumin on biochemical alterations and oxidative status against Dox-induced cardiotoxicity in rats.

 » Materials and Methods Top

Chemicals and drugs

Dox was a gift from Get Well Pharmaceuticals, India. Curcumin was purchased from Himedia Labs, India. Other chemicals were obtained from Sigma and analyzing kits were obtained from ERBA. All the chemicals were of the analytical grade.


Albinorats of either sex weighing 150-200 g procured from animal house of K.L.E.S's College of Pharmacy, Hubli, were used for the study after the clearance from Institutional Animal Ethical Committee (Ref. No. KLESCOPH/IAEC.Clear/06-07/08). Animals were acclimatized for one week to laboratory conditions before starting the experiment, they had free access to water and standard rat feed but 12 h prior to an experiment, the rats were deprived of food but not water.

Experimental protocol

After one week of acclimatization, the animals were randomly divided into 4 groups of 6 animals in each. Group 1 served as normal control and received normal saline 5 ml/kg body weight (i.p.). Group 2 animals were treated with Dox (2.5 mg/kg body weight, i.p.) in 6 equal injections alternatively for two weeks to make a total cumulative dose of 15 mg/kg body weight. Group 3 animals received curcumin (200 mg/kg body weight po) for two weeks and then alternatively with vehicle for next two weeks. Group 4 animals received curcumin (200 mg/kg body weight for two weeks) as a pretreatment followed by Dox administration as in group 2.

Enzyme assays

Thirty six hour after the last treatment, orbital blood samples were obtained under light ether anesthesia using heparinized microcapillaries for the estimation of biomarkers CPK [16] and LDH. [17] Normal as well as treated animals were observed for a period of three weeks after the last injection for the general appearance, behavior and mortality. At the end of three weeks post treatment period, animals were sacrificed under ether anesthesia and a midline abdominal incision was performed and heart tissue was quickly dissected out and washed in ice cold saline, dried on filter paper and weighed immediately. A portion of each heart was taken from all the groups and a 30% w/v homogenate was prepared in 0.9% buffered KCl (pH 7.4) for the estimation of glutathione (GSH), [18] malondialdehyde (MDA) [19] superoxide dismutase (SOD) [20] and catalase (CAT). [21] Orbital blood samples were collected before sacrificing the animals and used for estimation of AST, ALT [22] and ALP. [23] The remaining portion of the heart tissue was used for histopathological studies.

Histopathological studies

The heart tissue sections were fixed in 10% formalin. The specimens were processed by standard procedure and embedded in paraffin wax. The blocks were sectioned from the ventricular portion and stained according to the hematoxylin and eosin method and were examined by light microscopy.

Statistical analysis

The results are expressed as mean ± S.E.M. The results were analyzed using one-way ANOVA followed by Dunnett's multiple comparison test. Data was computed for statistical analysis by using Graph Pad Prism 5 Software.

 » Results Top

Effect of curcumin on Dox-induced cardiac toxicity was established by measuring cardiac biomarker enzymes and endogenous antioxidants and heart tissue histopathology.

General observation and mortality

The general appearance of all groups of animals was recorded throughout the study. In Dox-treated group, the animal fur became scruffy and developed a pink tinge. These rats also had red exudates around the eyes and nose, soft watery feces and enlargement of abdomen. These observations were significantly less in curcumin-treated group.

Gross anatomical changes of Dox -treated heart

The hearts of Dox-treated rats were dilated and both the atrium and the ventricle were enlarged and hypertrophic. The cardiac hypertrophy attributed to Dox treatment was almost completely prevented by curcumin pretreatment.

Heart weight, body weight and ratio of heart weight to body weight

Effect of Dox on heart weight, body weight, ratio of heart weight to body weight and mortality is shown in [Table 1]. The heart weight and ratio of heart weight to body weight in Dox-treated group significantly increased as compared to normal group. The heart weight and ratio of heart weight to body weight in Cur+Dox treated group was significantly less as compared to Dox.
Table 1: Effect of curcumin on body weight, heart weight, heart/body ratio and mortality in doxorubicin-treated rats

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Serum enzyme biomarkers

Animals treated with Dox showed significant increase in the levels of CPK and LDH compared to normal [Table 2]. Cur + Dox treated group shown significantly lower levels of CPK and LDH as compared to Dox treated group.
Table 2: Effect of curcumin on AST, ALT, ALP, CK and LDH enzyme activities in doxorubicin-treated rats

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The myocardial damage in the various treated groups was determined by estimating the activities of AST, ALT and ALP [Table 2]. These biochemical markers were significantly increased in the Dox group compared to control (P<0.01). Curcumin pretreatment group showed significant reduction in AST, ALT and ALP levels as compared to Dox-treated group.

Oxidant and antioxidant status

Effect of Dox on tissue lipid peroxidation, antioxidant and antioxidant enzymes is shown in [Table 3]. The MDA levels were increased. GSH, SOD and CAT levels were significantly decreased in Dox-treated group as compared to normal group. Cur+Dox treated group showed significant decrease (P<0.01) in the level of MDA and increase in the status of antioxidant and antioxidant enzymes.
Table 3: Effect of curcumin on oxidative status in doxorubicin-treated rats

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Histopathological studies

The histology of the heart tissue from normal and Cur treated animals showed normal morphological appearances, whereas in Dox-treated group loss of myofibrils and vacuolization of the cytoplasm were observed. The histology of heart tissues from Cur+Dox treated group showed less loss of myofibrils and vacuolization of the cytoplasm [Figure 1].
Figure 1: (a) Photomicrograph of normal group heart showing normal myocardial fibers and architecture. (b) Doxorubicin-treated group showing loss of myocardial fibers and vacuolated cells. (c) Curcumin-treated group showing no vacuolated cells and myofibers loss and normal architecture. (d) Curcumin + doxorubicin treated group showing scanty myocardial fibers loss and vacuolated cells.

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 » Discussion Top

The study reveals the cardioprotective effect of curcumin against Dox-induced cardiotoxicity in rats. Following lines of evidence can be emphasized from the present study. Curcumin, a yellow crystalline compound that has been traditionally used in medicine and culinary practices in India, possesses cardioprotective, hepatoprotective, chemopreventive effects against various cancers and lipid lowering properties. The present study is aimed to investigate the cardioprotective effects of oral administration of curcumin against Dox -induced cardiotoxicity.

In the Dox-treated group, the animal fur became scruffy and developed a pink tinge which in the later days of observation period was followed by red exudates around the eyes and nose. Necrosis was also observed at the site of Dox injection. These changes were less pronounced in case of curcumin pretreated group animals, which accounts for the effective cell protecting property of curcumin with anti-inflammatory, antioxidant and antifibrotic effect.

The Dox-treated rats showed increase in heart weight and decrease in body weight. Increase in the heart weight may be attributed to the enlarged, dilated and hypertrophic atrium and ventricles. However, all of the above changes were found inhibited in the Cur+Dox group.

The study revealed severe biochemical changes as well as oxidative damage in the cardiac tissue after the chronic treatment with Dox. Transaminases such as ALT and AST are liberated into the serum after extensive tissue injury. Because the heart muscle is rich in both (especially AST), it suggests that their increased level is an indicator of myocardial damage.

The Dox-treated group showed marked elevation in serum levels of AST and ALT as compared to vehicle-treated group. The mild elevations of AST have been associated with liver injury or myocardial infractions. Greater the injury size, higher the activity of AST. This result implies that the Dox when taken for long period of time could cause both liver and heart injury. A typical myocardial injury gives an AST/ALT ratio greater than 1. However, AST/ALT ratio less than 1 are found due to release of ALT from the affected liver. [24] Since the result showed AST / ALT ratio to be greater than 1 with higher doses over a long period of time, Dox is likely to lead myocardial damage.

In Cur+Dox treated group, AST and ALT levels significantly decreased as compared to Dox treated group; therefore, present results suggest that treatment of curcumin may inhibit myocardial damage. These findings confirm that curcumin is responsible for maintenance of normal structural and architectural integrity of cardiac myocytes, which can be accounted for membrane stabilizing property of curcumin, as evident from the near normal serum enzymatic activities of AST and ALT.

The serum ALP, LDH and CPK enzyme activities are important measures of both early and late phases of cardiac injury. It is reported that serum LDH and CPK were increased after Dox administration in mouse. The present results are in good agreement with our earlier findings. [10] ALP activity on endothelial cell surface is responsible, in part, for the conversion of adenosine nucleotides to adenosine, a potent vasodilator and anti-inflammatory mediator that can protect tissues from the ischemic damage that results from injury. This may account for the elevation of ALP in the Dox group, where tissue injury and inflammation are prominent. On the other hand, CPK and LDH are not specific for myocardial injury individually; however, evaluation of these enzymes together may be an indication of myocardial injury. In the preventive group, i.e. Cur +Dox, the ALP, LDH and CPK enzyme levels were decreased to a level near to that of control group, suggesting that curcumin may protect the myocardial tissue against Dox toxicity.

The mechanism of cardiotoxicity induced by Dox is not clearly known from the present study, although large body of evidence indicates toward the formation of oxygen free radicals, which can damage cells by lipid peroxidation. In rat treated with Dox, we found significant increase in heart tissue MDA levels suggesting increased lipid peroxidation. Cardiac tissue damage may be due to increased oxidative stress and depletion of antioxidants similarly in rats reported earlier. [25]

In our study, Dox treated rats showed increase in heart tissue MDA levels with decrease in levels of GSH, SOD and CAT, which confirms the oxidative stress and cardiac damage. Curcumin prevented the Dox-induced changes in MDA and enzyme levels. Significant increase in the GSH, SOD and CAT activity and decrease in lipid peroxidation in heart tissue of Cur+Dox treated groups was found. The study suggests the protective effect of curcumin.

It is commonly accepted that SOD protects against the free radical injury by converting O 2- radical to H 2 O 2 and prevent the formation of OH radicals through O 2- driven Fenton reaction [26] and the H 2 O 2 can be removed by catalase. Administration of curcumin improved the antioxidant status and thereby preventing the damage to the heart, mainly because of the antioxidant sparing action of curcumin.

The antioxidant mechanism of curcumin may include one or more of the following interactions. Scavenging or neutralizing of free radicals, [27] inhibition of oxidative enzymes like cytochrome P 450 , [28] oxygen quenching and making it less available for oxidative reaction, interacting with oxidative cascade and preventing its outcome [29] and disarming oxidative properties of metal ions such as iron. [30] Thus, in this work, curcumin effectively prevented tissue damage by decreasing the oxidative stress and restoring the antioxidant status.

Curcumin protects Dox-induced biochemical and histological changes in the cardiac tissue of rats either by restoring endogenous antioxidant activity or as antioxidant/both. A similar action of scavenging of Dox-induced free radicals by curcumin in the present study cannot be ruled out.

The vehicle-treated rats did not show any morphological changes and heart showed normal appearance. The cardiac muscle fibers were found to be of uniform size, shape, and configurations with no inflammatory cell infiltrates were present. Cardiomyopathy occurred in all rats injected with Dox as illustrated by the appearance of enlarged, swollen mitochondria and vacuoles within the cytoplasm. Dox produced massive change in the myocardium showing a varying degree of vacuolar changes in the cardiac muscle fibers mainly in the form of degeneration of myocardial tissue, vacuolization of the cardiomyocytes, myofibrillar loss, myocardial hypertrophy and fragmentation of the nuclei. Histopathological report suggest curcumin pretreated group attenuates the Dox -induced cardiac toxicity. The histopathological changes observed in the Dox -treated rats were similar to those previously reported. [10] This cardioprotection was apparent by fewer and less extensively swollen cardiac mitochondria and myofibrils loss.

Finally we conclude that the cardiotoxicity induced by Dox is related with oxidative stress. Anti-proliferative, anti-initiation and free radical scavenging properties of curcumin may boost myocardial integrity and attenuate the cardiac toxicity.

Curcumin has shown to be cardioprotective, which may be attributed to its potent antioxidant properties. Our study suggests that curcumin may be considered as a potentially useful candidate in combination with Dox to limit free radical mediated organ injury.

 » References Top

1.Zhon S, Palmeira CM, Wallace KB. Doxorubicin induced persistent oxidative stress to cardiac myocytes. Toxicol Lett 2001;121:151-7.  Back to cited text no. 1
2.Lenaz L, Page J. Cardiotoxicity of adriamycin and related anthracyclines. Cancer Treat Rev 1976;3:111-20.  Back to cited text no. 2
3.Myers CF, McGuire WP,Liss RH. Adriamycin: The role of lipid peroxidation in cardiac toxicity and tumor response. Science 1977;197:165-7.  Back to cited text no. 3
4.Bier CC, Jaenke RS. Function of myocardial mitochondria in the Adriamycin induced cardiomyopathy of rabbits. J Natl Cancer Inst 1976;57:1091-4.   Back to cited text no. 4
5.Geetha A, Devi CS. Effect of Doxorubicin on heart mitochondrial enzymes in rats: A protective role for alphatocopherol. Indian J Exp Biol 1992;30:615-8.   Back to cited text no. 5
6.Bristow MR, Sageman WS, Scott RH. Acute and chronic cardiovascular effects of doxorubicin in dog. J Cardiovasc Pharmacol 1980;2:487-515.   Back to cited text no. 6
7.Loren EW. Doxorubicin induces cardiomyocyte dysfunction via p38 MAP kinase dependent oxidative stress mechanism. Cancer Detect Prev 2005;29:294-9.  Back to cited text no. 7
8.Brown LA, Harris FL, Jones DP. Ascorbate deficiency and oxidative stress inalveolar type II cell. Am J Physiol 1997;273:782-8.  Back to cited text no. 8
9.Hanaa HA, Fathia M, Gamal AE, Senot HD.Cardioprotective activity of melatonin and its novel synthesized derivatives on doxorubicin induced cardiotoxicity. Bioorg Med Chem 2005;13:1847-57.  Back to cited text no. 9
10.Koti BC, Vishwanathaswamy AH,Wagwade J, Thippeswamy AH.Cardioprotective effect of lipistatagainst doxorubicin induced myocardial toxicity in albino rats. Indian J Exp Biol 2009;47:41-6.  Back to cited text no. 10
11.Thurich T, Schneider M. Cardioprotective effects of dihydrolipoic acid and tocopherol in right heart hypertrophy during oxidative stress. Arzneimittelforschung 1998;48:13-21.  Back to cited text no. 11
12.Nazeyrollas P, Prevost A, Baccard N, Manot L, Devillier P, Millart H.Effects of amifostine on perfused isolated rat heart and on acute dox-induced cardiotoxicity. Cancer Chem Pharmcol 1993;43:227-32.  Back to cited text no. 12
13.Nirmala C, Puvanakrishnan R. Protective role of curcumin against isoproterenol induced myocardial infarction in rats. Mol Cell Biochem 1996;159:85-93.  Back to cited text no. 13
14.MohantyaI, Singh AD, Amit D, JoshiaS, Keval KT, GuptaSK. Protective effects of Curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms. Life Sci 2004;75:1701-9.  Back to cited text no. 14
15.Chainani WN. Safety and anti-inflammatory activity of Curcumin: A component of tumeric (Curcuma longa). J Altern Complement Med 2003;9:161-8.  Back to cited text no. 15
16.Rosalki SB. An improved procedure for serum creatine phosphokinase determination. J Lab Clin Med1967;69:696-705.  Back to cited text no. 16
17.Henry RJ, Chiamori N, Goiub OJ,Berkman S. Revised spectrophotometric methods for the determination of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase and lactic acid dehydrogenase. Am J Clin Pathol 1960;34:381-98.  Back to cited text no. 17
18.Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959;82:70-7.  Back to cited text no. 18
19.Ohkawa H, Ohish N, Yogi K. Assay for lipid peroxidase in animal tissues by thiobarbituric acid. Anal Biochem 1979;95:351-8.  Back to cited text no. 19
20.Mishra HP, Fridovich I. The role of superoxide anion in the auto-oxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem1972;247:3170-5.  Back to cited text no. 20
21.Clairborne A. Catalase activity. In:Greenwald RA, editor. Handbook of Methods for Oxygen Radical Research. Boca Raton, FL:CRC Press; 1985. p. 283.  Back to cited text no. 21
22.Reitman S, Frankel AS. A colorimetric method for the determination of serum glutamyl oxalacetic acid glutamyl pyruvate transaminase. Am J Clin Pathol 1957;28:56-63.  Back to cited text no. 22
23.Kind PR, King EJ. Estimation of plasma phosphatase by determination of hydrolysed phenol with antipyrine. J Clin Pathol 1954;7:322-6.  Back to cited text no. 23
24.Visser MP, Krill MT, Muijtjens AM, Willems GM, Hermens WT. Distribution of enzymes in dog heart and liver:Significance for assessment of tissue damage from data on plasma enzyme activities. Clin Chem 1981;11:1845-50.  Back to cited text no. 24
25.Doroshow JH. Effect of anthracycline antibiotics on oxygen radical formation in rat heart. Cancer Res 1983;43:460-72.  Back to cited text no. 25
26.McCord JM, FridovichI. The utility of superoxide dismutase in studying free radical reactions. J Biol Chem 1969;244:6049-55.   Back to cited text no. 26
27.Grisham M, McCord J. Chemistry and cytotoxicity of reactive oxygen metabolites. In: Taylor A, Matalon S, Ward P, editors.Physiology of oxygen radicals. Bethesda: Am Physiol Soc;1986. p.1-18.  Back to cited text no. 27
28.Appiah R, Commandeur JN,Vermeulen NP. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products.Toxicology2007;235:83-91.  Back to cited text no. 28
29.Sandur SK, Ichikawa H, Pandey MK, Kunnumakkara AB, Sung B, Sethi G, et al. Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). Free Radic Biol Med 2007;43:568-80.   Back to cited text no. 29
30.Miriyala S, Panchatcharam M, Rengarajulu P. Cardioprotective effects of curcumin. Adv Exp Med Biol 2007;595:359-77.  Back to cited text no. 30


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  [Table 1], [Table 2], [Table 3]

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Journal of Ayurveda and Integrative Medicine. 2021;
[Pubmed] | [DOI]
22 NMCP-2 polysaccharide purified from Morchella conica effectively prevents doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress
Na Xu, Yi Lu, Xinmiao Yao, Rui Zhao, Zhebin Li, Jialei Li, Yinglei Zhang, Bo Li, Ye Zhou, Huifang Shen, Liqun Wang, Kaixin Chen, Li Yang, Shuwen Lu
Food Science & Nutrition. 2021; 9(11): 6262
[Pubmed] | [DOI]
23 Mechanisms of doxorubicin-mediated reproductive toxicity – A review
Uma Priya Mohan, Tirupathi Pichiah P.B., Syeda Thabassum Akhtar Iqbal, Sankarganesh Arunachalam
Reproductive Toxicology. 2021; 102: 80
[Pubmed] | [DOI]
24 Curcumin Loaded and Co-loaded Nanosystems: A Review from a Biological Activity Enhancement Perspective
Andrea M. Araya-Sibaja, Krissia Wilhelm, Gustavo A. González-Aguilar, José R. Vega-Baudrit, Norma J. Salazar-López, Jesús A. Domínguez-Avila, Mirtha Navarro-Hoyos
Pharmaceutical Nanotechnology. 2021; 9(2): 85
[Pubmed] | [DOI]
25 Sesamol Upregulates Death Receptors and Acts as a Chemosensitizer in Solid Ehrlich Carcinoma Model in Mice
Nesma A. Abd Elrazik, Mohamed El-Mesery, Amro El-Karef, Laila A. Eissa, Amal M El Gayar
Nutrition and Cancer. 2021; : 1
[Pubmed] | [DOI]
26 Curcumin-coated gold nanoparticles attenuate doxorubicin-induced cardiotoxicity via regulating apoptosis in a mouse model
Zeynab Sharifiaghdam, Fereshteh Dalouchi, Maryam Sharifiaghdam, Elnaz Shaabani, Fatemeh Ramezani, Farnaz Nikbakht, Yaser Azizi
Clinical and Experimental Pharmacology and Physiology. 2021;
[Pubmed] | [DOI]
27 Attenuation of Docetaxel-induced Oxidative Stress and Apoptosis in HEK 293 Human Embryonic Kidney Cells by Curcumin Treatment
Süleyman ILHAN
Celal Bayar Üniversitesi Fen Bilimleri Dergisi. 2021;
[Pubmed] | [DOI]
28 Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review
Badriyah Shadid Alotaibi, Munazza Ijaz, Manal Buabeid, Zelal Jaber Kharaba, Hafiza Sidra Yaseen, Ghulam Murtaza
Drug Design, Development and Therapy. 2021; Volume 15: 4713
[Pubmed] | [DOI]
29 Sinapic Acid Ameliorates Oxidative Stress, Inflammation, and Apoptosis in Acute Doxorubicin-Induced Cardiotoxicity via the NF-?B-Mediated Pathway
Yousef A. Bin Jardan, Mushtaq Ahmad Ansari, Mohammad Raish, Khalid M. Alkharfy, Abdul Ahad, Fahad I. Al-Jenoobi, Nazrul Haq, Mohd Rashid Khan, Ajaz Ahmad
BioMed Research International. 2020; 2020: 1
[Pubmed] | [DOI]
30 Protective effects of olmesartan and l-carnitine on doxorubicin-induced cardiotoxicity in rats
Malek M. Aziz, Mai A. Abd El Fattah, Kawkab A. Ahmed, Helmy M. Sayed
Canadian Journal of Physiology and Pharmacology. 2020; 98(4): 183
[Pubmed] | [DOI]
31 Comparison of exercise training and estrogen supplementation on mast cell-mediated doxorubicin-induced cardiotoxicity
Sukanya Phungphong, Anusak Kijtawornrat, Theerachat Kampaengsri, Jonggonnee Wattanapermpool, Tepmanas Bupha-Intr
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2020; 318(5): R829
[Pubmed] | [DOI]
32 Vanillin Prevents Doxorubicin-Induced Apoptosis and Oxidative Stress in Rat H9c2 Cardiomyocytes
Ivana Sirangelo, Luigi Sapio, Angela Ragone, Silvio Naviglio, Clara Iannuzzi, Daniela Barone, Antonio Giordano, Margherita Borriello
Nutrients. 2020; 12(8): 2317
[Pubmed] | [DOI]
33 Aloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokines
Lalit Birari, Shivani Wagh, Kalpesh R. Patil, Umesh B. Mahajan, Banappa Unger, Sateesh Belemkar, Sameer N. Goyal, Shreesh Ojha, Chandragouda R. Patil
Cancer Chemotherapy and Pharmacology. 2020; 86(3): 419
[Pubmed] | [DOI]
34 Antioxidant, antiapoptotic, and antifibrotic effects of the combination of liposomal resveratrol and carvedilol against doxorubicin-induced cardiomyopathy in rats
Abeer Alanazi, Laila Fadda, Ahlam Alhusaini, Rehab Ahmad
Journal of Biochemical and Molecular Toxicology. 2020; 34(7)
[Pubmed] | [DOI]
35 The iron chelating activity of Gundelia tournefortii in iron overloaded experimental rats
Kamal Mansi, Yahia Tabaza, Talal Aburjai
Journal of Ethnopharmacology. 2020; 263: 113114
[Pubmed] | [DOI]
36 Cardiotoxicity of doxorubicin-based cancer treatment: What is the protective cognition that phytochemicals provide us?
Cun Liu, Xiaoran Ma, Jing Zhuang, Lijuan Liu, Changgang Sun
Pharmacological Research. 2020; 160: 105062
[Pubmed] | [DOI]
37 Curcumin as a preventive or therapeutic measure for chemotherapy and radiotherapy induced adverse reaction: A comprehensive review
Sadaf Akbari, Elnaz Kariznavi, Mahdi Jannati, Sepideh Elyasi, Zahra Tayarani-Najaran
Food and Chemical Toxicology. 2020; 145: 111699
[Pubmed] | [DOI]
38 Obstacles against the Marketing of Curcumin as a Drug
Kambiz Hassanzadeh, Lucia Buccarello, Jessica Dragotto, Asadollah Mohammadi, Massimo Corbo, Marco Feligioni
International Journal of Molecular Sciences. 2020; 21(18): 6619
[Pubmed] | [DOI]
39 Plant Fortification of the Diet for Anti-Ageing Effects: A Review
Daljeet Singh Dhanjal, Sonali Bhardwaj, Ruchi Sharma, Kanchan Bhardwaj, Dinesh Kumar, Chirag Chopra, Eugenie Nepovimova, Reena Singh, Kamil Kuca
Nutrients. 2020; 12(10): 3008
[Pubmed] | [DOI]
40 Curcumin ameliorated myocardial infarction by inhibition of cardiotoxicity in the rat model
Mehdi Rahnavard, Mehdi Hassanpour, Mahdi Ahmadi, Morteza Heidarzadeh, Hassan Amini, Masoumeh Zirak Javanmard, Mohammad Nouri, Reza Rahbarghazi, Nasser Safaie
Journal of Cellular Biochemistry. 2019; 120(7): 11965
[Pubmed] | [DOI]
41 Cardioprotective effects of curcumin and carvacrol in doxorubicin-treated rats: Stereological study
Zahra Jafarinezhad, Ali Rafati, Farzaneh Ketabchi, Ali Noorafshan, Saied Karbalay-Doust
Food Science & Nutrition. 2019; 7(11): 3581
[Pubmed] | [DOI]
42 The effect of curcuma (Curcuma xanthorrizha roxb.) extract as an adjuvant of captopril therapy on cardiac histopathology of male mice (Mus musculus) with hypertension
Nursela Hijriani, Lilik Yusetyani, Didik Hasmono
Journal of Basic and Clinical Physiology and Pharmacology. 2019; 30(6)
[Pubmed] | [DOI]
43 Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity
Rui Guo, Yinan Hua, Jun Ren, Karin E. Bornfeldt, Sreejayan Nair
Cell Death & Disease. 2018; 9(6)
[Pubmed] | [DOI]
S. K Nimbal, B. C Koti
INDIAN DRUGS. 2018; 55(12): 27
[Pubmed] | [DOI]
45 Tetrahydrocurcumin ameliorates homocysteine-mediated mitochondrial remodeling in brain endothelial cells
Jonathan C. Vacek, Jyotirmaya Behera, Akash K. George, Pradip K. Kamat, Anuradha Kalani, Neetu Tyagi
Journal of Cellular Physiology. 2018; 233(4): 3080
[Pubmed] | [DOI]
46 Cadmium-induced toxicity is rescued by curcumin: A review
Mohammad Mohajeri, Mehdi Rezaee, Amirhossein Sahebkar
BioFactors. 2017; 43(5): 645
[Pubmed] | [DOI]
47 Curcumin: A new candidate for melanoma therapy?
Hamed Mirzaei, Gholamreza Naseri, Ramin Rezaee, Mohsen Mohammadi, Zarrin Banikazemi, Hamid Reza Mirzaei, Hossein Salehi, Mostafa Peyvandi, John M. Pawelek, Amirhossein Sahebkar
International Journal of Cancer. 2016; 139(8): 1683
[Pubmed] | [DOI]
M Chakraborty, A. Bhattacharjee, J. V. Kamath
INDIAN DRUGS. 2016; 53(11): 65
[Pubmed] | [DOI]
49 Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature
Wioleta Grabowska, Malgorzata Suszek, Maciej Wnuk, Anna Lewinska, Emilia Wasiak, Ewa Sikora, Anna Bielak-Zmijewska
Oncotarget. 2016; 7(15): 19201
[Pubmed] | [DOI]
50 Ameliorative effect of certain antioxidants against mercury induced genotoxicity in peripheral blood lymphocytes
Tapan A. Patel,Mandava V. Rao
Drug and Chemical Toxicology. 2015; : 1
[Pubmed] | [DOI]
51 Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner
Wioleta Grabowska,Karolina Kucharewicz,Maciej Wnuk,Anna Lewinska,Malgorzata Suszek,Dorota Przybylska,Grazyna Mosieniak,Ewa Sikora,Anna Bielak-Zmijewska
AGE. 2015; 37(1)
[Pubmed] | [DOI]
52 Curcumin, a component of golden spice: From bedside to bench and back
Sahdeo Prasad,Subash C. Gupta,Amit K. Tyagi,Bharat B. Aggarwal
Biotechnology Advances. 2014;
[Pubmed] | [DOI]
53 Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase – Carbonyl reductase 1
Jan Hintzpeter,Jan Hornung,Bettina Ebert,Hans-Jörg Martin,Edmund Maser
Chemico-Biological Interactions. 2014;
[Pubmed] | [DOI]
54 Mitochondria-mediated mitigatory role of curcumin in cisplatin-induced nephrotoxicity
Mohammad Waseem,Pooja Kaushik,Suhel Parvez
Cell Biochemistry and Function. 2013; : n/a
[Pubmed] | [DOI]
55 Isorhamnetin Protects against Doxorubicin-Induced Cardiotoxicity In Vivo and In Vitro
Sun, J., Sun, G., Meng, X.,Guo, P., Sun, X.
PLoS ONE. 2013; 8(5): e64526
56 Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome?
Amirhossein Sahebkar
BioFactors. 2013; 39(2): 197
[Pubmed] | [DOI]
57 Are Curcuminoids Effective C-Reactive Protein-Lowering Agents in Clinical Practice? Evidence from a Meta-Analysis
Amirhossein Sahebkar
Phytotherapy Research. 2013; : n/a
[Pubmed] | [DOI]
58 Switching to a low-fat diet attenuates the intensified doxorubicin cardiotoxicity associated with high-fat feeding
David S. Hydock,Chia-Ying Lien,Brock T. Jensen,Carole M. Schneider,Reid Hayward
Cancer Chemotherapy and Pharmacology. 2013; 71(6): 1551
[Pubmed] | [DOI]
59 Mitochondrial dysfunction mediated cisplatin induced toxicity: Modulatory role of curcumin
Mohammad Waseem,Suhel Parvez
Food and Chemical Toxicology. 2013; 53: 334
[Pubmed] | [DOI]
60 Modulation of disease related immune events by demethoxycurcumin against autoimmune arthritis in rats
Sumeet Gullaiya,Ashish Nagar,Vishal Dubey,Varun Singh,Ashok Kumar,Poonam Tiwari,Shyam Sundar Agrawal
Biomedicine & Aging Pathology. 2013; 3(1): 7
[Pubmed] | [DOI]
61 Pretreatment Hepatoprotective Effect of Regular Aerobic Training Against Hepatic Toxicity Induced by Doxorubicin In Rats
Fatemeh Zolfagharzadeh,Valiollah Dabidi Roshan
Asian Pacific Journal of Cancer Prevention. 2013; 14(5): 2931
[Pubmed] | [DOI]
62 Pretreatment Effect of Running Exercise on HSP70and DOX-Induced Cardiotoxicity
Vahid Shirinbayan,Valiollah Dabidi Roshan
Asian Pacific Journal of Cancer Prevention. 2012; 13(11): 5849
[Pubmed] | [DOI]
63 Is Short-term Exercise a Therapeutic Tool for Improvement of Cardioprotection Against DOX-induced Cardiotoxicity? An Experimental Controlled Protocol in Rats
Javad Ashrafi,Valiollah Dabidi Roshan
Asian Pacific Journal of Cancer Prevention. 2012; 13(8): 4025
[Pubmed] | [DOI]


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